慢性乙型病毒性肝炎病人血清瘦素测定及其意义

CLINICAL SIGNIFICANCE OF DETECTING SERUM LEPTIN LEVELS IN PATIENTS WITH VIRAL HEPATITIS B

目的 探讨血清瘦素（leptin）在慢性乙型病毒性肝炎（乙肝）发病中所起作用及乙肝对血清leptin水平的影响。方法 采用放射免疫分析法（RIA）检测并比较86例慢性乙肝病人、80例健康体检者（正常对照组）血清leptin水平，并分析其与各种生化指标的关系。结果 男女慢性乙肝病人血清leptin水平均较正常对照组高（t=9．50、6．82，P〈0．01）；HBsAg（＋）＋HBeAg（＋）＋HBcAb（＋）病人和HBsAg（＋）＋HBeAb（＋）＋HBcAb（＋）病人血清leptin水平差异无显著性（P〉0．05）；血清leptin水平与谷丙转氨酶（ALT）、谷草转氨酶（AST）呈显著性正相关（r=0．469～O．624，P〈0．05），而与血糖（Glu）、总胆固醇（TC）无明显相关性（r=0．003～0．245，P〉0．05）。结论 leptin可以作为一个判断慢性乙肝病人肝脏炎症严重程度的指标。

Objective To explore the role of serum leptin in morbidity of viral hepatitis B （HVB）. Methods Levels of serum leptin of patients with HVB （n=86）, and of control subjects （n=80） were determined by radioimmunoassay. Liver functions （ALT, AST）, glucose （Glu）, and total cholesterol （TC） were evaluated too. Results Compared with the controls, the levels of serum leptin were significantly higher in patients with HBV （t=9.50,6.82;P〈0.01）. Levels of serum leptin were positively correlated with levels of ALT and AST （r=0. 469-0. 624,P〈0.05）, hut not with levels of Glu and TC （r=0. 003-0. 245, P〉0.05）. Conclusion Levels of serum leptin can be regarded as an index reflecting the severity of liver inflammation in patients with chronic viral hepatitis B.