三七皂苷对高血压病人血压及vWF、t-PA、PAI-1含量的影响

EFFECTS OF PANAX NOTOGINSENG SAPONINS ON PLASMA vWF,t-PA AND PAI-1 IN PATIENTS WITH HYPERTENSION

目的 观察三七皂苷对高血压的疗效，并探讨其改善血栓前状态的作用。方法 60例病人随机分为治疗组（30例）和对照组（30例）。对照组给予常规西药治疗，治疗组在对照组治疗的基础上配合三七皂苷治疗，疗程均为3周。观察2组治疗前后血压、组织型纤溶酶原激活物（t-PA）和组织型纤溶酶原激活剂抑制物1（PAI-1）、血管血友病因子（vWF）的变化。结果 治疗组对血压影响明显高于对照组（t=13．15、23．62，P〈0．01）；且治疗组降低vWF、PAI-1，升高t-PA作用优于对照组（t=6．54～10．44，P〈0．01）。结论 三七皂苷降压效果确切，并具有保护血管内皮、改善血栓前状态作用，对高血压病人靶器官保护有积极作用。

Objective To investigate the effects of Panax Notoginseng Saponins （PNS） on essential hypertension and prethrombotic state. Methods Sixty patients with essential hypertension were equally divided into PNS-treated group and con trol group. The treated group was given PNS for three weeks in addition to routine western medicine for both groups. The blood pressure, tissueplasminogen activator （t-PA）, plasminogen activator inhibitor1 （PAI-1）, and von Willebrand Factor （vWF） were measured before and after the treatment. Results The decrease of the blood pressure was more obvious in PNS-treated group （t= 13.15,23.62; P〈0. 01）, similarly decrease of the vWF, PAL1 and increase of t-PA were also more obvious in PNS-treated group （t=6.54- 10.44, P〈0.01）. Conclusion PNS can effectively decrease the blood pressure, protect the vascular endothelium and improve the prethrombotic state of essential hypertension.