胸腔内注入尿激酶治疗结核性渗出性胸膜炎的效果

EFFECT OF INTRAPLEURAL APPLICATION OF UROKINASE ON TUBERCULOUS EXADATIVE PLEURISY

目的 探讨胸腔内注入尿激酶治疗结核性渗出性胸膜炎的效果。方法 确诊的结核性渗出性胸膜炎病人103例，随机分为尿激酶组和对照组，均应用抗结核药物治疗，及时胸腔穿刺抽液，尿激酶组于每次抽液后将尿激酶10万单位用10mL生理盐水溶解后注入胸膜腔。结果 尿激酶组的抽液总量大于对照组（t=3．83，P〈0．01）；胸腔积液吸收时间、胸膜厚度、胸腔穿刺次数均较对照组小（t=5．08～15．38，P〈0．01）；第3秒呼气肺活量大于对照组（t=2．77，P〈0．01）。结论 胸腔内注射尿激酶治疗结核性渗出性胸膜炎可以减轻胸膜肥厚程度，改善肺功能。

Objective To observe the efficacy of intrapleural application of urokinase for tuberculous exadative pleurisy. Methods This study consisted of 103 patients with tuberculous exadative pleurisy, who were randomly divided into two groups： urokinase and control. Antituberculosis drugs were given and pleural effusion was aspirated to all of them, and urokinase, 100 000 U, was administered intrapleurally after each aspiration for those in urokinase group. Results The total volume of fluid aspirated in the urokinase group was more than that in the control （t= 3.83,P〈0.01）. The duration of absorption of the effusion was shorter, the pleura was thinner, and the number of aspiration was fewer, in urokinase group （t=5.08-15.38,P〈0.01）, the lung function （FEV3） was better as well （t=2. 77,P〈0.01）. Conclusion Intrapleural use of urokinase can reduce thickening of the pleura and improve lung function.