红霉素肠道吸收机理及最佳吸收部位研究

Studies of Absorption Mechanism and the Best Absorption Segment of Erythromycin in situ

采用在体大鼠肠段回流实验，对红霉素肠段最佳吸收部位及吸收机理进行研究。结果表明，红霉素在十二指肠的吸收明显高于其它肠段，表明十二指肠是红霉素的最佳吸收部位。药浓在０．０５～２ｍｇ／ｍｌ的范围内，无高浓度饱和现象，肠壁通透系数也保持基本不变，表明红霉素在肠道中主要通过被动转运吸收。

To clarify the difference in the absorption of erythromycin base(EM) from varied intestinal segments, the absorption and intestinal wall permeability were investigated using in situ perfusion method in the rat. Compared with other segments, significent higher percentage of EM disappeared from duodenum after it was perfused at same concentration for 2 hours. It is indicated that the duodenum was the best segment for EM absorption from rat intestine. The mechanism of EM absorption from intestine was investigated at different concentrations. When the concentration was raised from 0.05 to 2.0 mg/ml, the uptake of EM increased and did not appear saturable, whereras the permeability cofficience was kept at an equilibrium level. Those indicated that the absorption of EM by intestine is majorly via passive transport mechanism.