前列腺素E_1对肺心病心衰疗效的观察

Efficacy of prostaglandin E 1 in treatment of cor pulmonale patients with heart failure

探讨前列腺素Ｅ１静脉滴注对肺心病心衰的疗效。方法对３０例肺心病心衰患者，应用前列腺素Ｅ１（ＰＧＥ１）２００μｇ／ｄ静脉滴注，疗程５天。于治疗前后同步检测内源性洋地黄因子（ＥＤＦ）、过氧化脂质（ＬＰＯ）、超氧化物歧化酶（ＳＯＤ）及动脉血氧分压（ＰａＯ２）、动脉血二氧化碳分压（ＰａＣＯ２）和观察症状体征变化，并与对照组（不用ＰＧＥ１）的３０例肺心病心衰患者及２０例健康者进行比较。结果两组肺心病心衰患者的ＥＤＦ、ＬＰＯ显著高于健康组（Ｐ＜０．００１），ＳＯＤ含量则显著降低（Ｐ＜０．００１）。治疗组病例治疗后ＥＤＦ、ＬＰＯ较治疗前显著降低（Ｐ＜０．００１），ＳＯＤ含量则显著升高（Ｐ＜０．００１），症状体征及血气参数显著改善（Ｐ＜０．０１～０．００１）。对照组（不用ＰＧＥ１）病例的ＥＤＦ、ＬＰＯ、ＳＯＤ、血气参数及症状体征，于治疗前、后无显著变化（Ｐ＞０．０５）。结论ＰＧＥ１对肺心病心衰患者确有较好的疗效。

s Objective Toinvestigate the effects of prostaglandin E 1(PGE 1)by intravenous drip in cor pulmonale patients with heart failure.Methods Thirty caseas of cor pulmonale with heart failu rewere treated with PGE 1 at adose of 200 μg.d -1 for 5 days and in 30 patients with cor pulmona le he art failure(no PGE 1)and in20healthy subjects as controls,The level of serum endogenous digoxin li ke fac tor(EDF),serum lipoid superoxide(LPO),serum superoxide dismutase(SOD)and blood PaO 2,Pa CO 2 were determined.Their symptoms and signs were observed before and after treatment.Results The level of serum EDF,LPO were significantly increased(P<0.001)and serum SOD was significant ly decreased(P<0.001)in PGE 1 group and controls group(no PGE 1)as compared with healthy sub jects.In PGE 1 group the level of serum EDF,LPO were markedly decreased(P<0.001),and serum SOD was markedly elevated(P<0.001),and their symptoms,signs and blood gas parameters had noteworthyly improved(P<0.01～0.001).But in the control group(no PGE 1)the level of serum EDF,LPO,SOD,blood gas parameters and their symptoms and signs,showed no significant differen ce(P>0.05).Conclusions PGE 1 is effective in therapy of cor pulmonale with heart failure.Treatme ntwith PGE 1 shows more significant benefits in cor pulmonale patients with heart failure