冷循环射频消融输出功率及作用时间与凝固灶大小的关系

Relationship of the size of the coagulation zone induced by cooled-tip radiofrequency ablation with working time and power output

目的:分析冷循环射频消融输出功率及作用时间与牛肝组织凝固灶大小的关系。方法:实验于2006-11/2007-01在中山大学附属第二医院超声科治疗室完成。对新鲜离体牛肝组织进行冷循环射频消融,测量在不同作用时间(6,8,10,12,14min)和输出功率(50,60,70,80,90W)组合条件下凝固灶纵径(Dv)及横径()大小,并Dt分析凝固灶大小与作用时间、输出功率的关系。结果:在作用时间(14min)和输出功率(90W)范围内,凝固灶大小与作用时间和输出功率有高度线性相关关系,凝固灶纵径与作用时间、输出功率的相关系数r=0.951,P<0.001,二元线性回归方程为Dv=11.986+0.833T+0.172P(T为消融时间,P为输出功率);凝固灶横径与作用时间、输出功率的相关系数r=0.977,P<0.001,二元线性回归方程为Dt=9.246+0.907T+0.102P。结论:冷循环射频消融输出功率及作用时间与牛肝组织凝固灶大小呈正相关。

AIM： To analyze the relationship between the size of coagulation zone induced by cooled-tip radiofrequency ablation （RFA） in fresh bovine liver and working time （T） together with power output （P）. METHODS： This experiment was carried out from November 2006 to January 2007 at Department of Ultrasound in Medicine in the Second Affiliated Hospital of Sun Yat-sen University. After RFA was performed in fresh bovine liver in vitro, the vertical diameters （Dv） and transverse diameters （Dt） of coagulation zones were measured in different working times （6, 8, 10, 12, 14 minutes） and different power outputs （50, 60, 70, 80, 90 W）. The correlation was analyzed between the size of coagulation zone and working time together with power output. RESULTS： Within 14 minutes and 90 W, there was a high linear relationship between the size of coagulation zone and working time together with power output. The regression equation of Dv to working time and power output was Dv=11.986＋0.833T＋0.172P （r =0.951, P 〈 0.001）; the regression equation of Dt to working time and power output was Dt=9.246＋0.907T＋0.102P （r =0.977, P 〈 0.001）. CONCLUSION： The size of coagulation zone in fresh bovine liver is positively correlated with working time and power output of the cooled-tip RFA.