昆虫性信息素的固相合成

The synthesis of insect sex pheromones on solid phase

本综述阐明昆虫性信息素固相合成的最新成就。C.C.Leznoff 开创了昆虫性信息素的固相合成,并合成了一系列信息素。他以二醇为原料,以聚合物三苯甲基氯为保护剂。陈德恒等将保护剂改成聚合物三苯甲基氯硅烷,产率比前人有所提高。陈家威等大大改进了前两人的线路,简化了步骤,只抓住关键的一步进行固相合成,总产率比前人提高得更多。

This review covers the development,recent research progressabout the synthesis of insect sex pheromones on solid phase.C.C.Leznoff,et.al.have synthesized a large scale of insect sex pheromones on solid phase.Heused polymeric trityl chloride as monofunctional protecting reagent of diol.ButChan Tak Hang,et.al.changed the polymeric protecting reagent into polymer-bound triphenyl chlorosilane.Its yield is higher than before.Chen Jia Wei,et.al.modified above two methods:simplified the steps,only seized the keystep on solid phase.The yield also increased much more than above route.