Polo样激酶1在胶质瘤中的表达

Expression and significance of Polo-like kinase 1 in gliomas

目的:检测Polo样激酶1在胶质瘤中的表达,探讨其临床意义。方法:应用免疫组织化学方法检测PLK1的表达,并对患者进行随访。结果:正常脑组织未见PLK1明显表达,各级别胶质瘤均有PLK1表达。Ⅰ级～Ⅱ级、Ⅲ级和Ⅳ级PLK1阳性率分别为43.8%、81.8%和100%。(Ⅲ～Ⅳ)级和(Ⅰ～Ⅱ)级之间PLK1表达有显著性差异(P<0.005),且与病理级别呈正相关(r=0.437,P<0.05)。高级别组和低级别组患者两年生存率分别为31.2%和70.8%,二者有显著性差异(P<0.005)。结论:PLK1在胶质瘤中的表达与肿瘤病理级别和患者预后密切相关,可作为判断预后的重要指标。

Objeetive：To study the expression and clinical significance of PLK1 in gliomas. Methods： PLK1 was detected by immunohistological stain in 3 normal brain tissues and 40 cases of glioma specimens. All patiens were followed up. Results ： No expression of PLK1 was found in the normal brain tissues. The positive ratio of gliomas grade Ⅰ -Ⅱ, Ⅲ and Ⅳ for PLK1 was 43.8% ,81.8% and 100% respectively. There was significant difference between glioma grade Ⅰ-Ⅱ and glioma grade Ⅲ - Ⅳ （ P 〈 0.05 ）. The patients with high PLK1 expression survived significantly shorter than those with low PLK1 expression （P 〈 0.05 ）. Conclusion：PLK1 was closely related to the tumor＇s pathological grade and patient＇s prognosis. It could play an important role in prognosis evaluation.