银翘伤风胶囊质量标准的研究

Study on Quality Standards for Yinqiaoshangfeng Capsules

目的:确定银翘伤风胶囊质量标准。方法:通过薄层鉴别方法(TLC)对处方中金银花、牛黄、芦根、甘草进行定性鉴别。运用高效液相色谱法(HPLC)对连翘中的连翘苷进行含量测定。结果:薄层色谱斑点清晰,阴性对照无干扰。含量测定连翘苷量在0.199-0.991μg之间有良好的线性关系,相关系数r=0.999 9。回收率为99.7%,RSD=0.48%(n=5)。结论:所建立的方法可靠,能准确地进行定性、定量检测,可用于该制剂的质量控制。

Objective： To establish the quality standard for Yinqiaoshangfeng capsules. Methods： Flos Lonicerae, Calculus Bovis, Rhizoma Phragmitis and Radix Glycyrrhizae were identified by TLC. Forsythin was determined by an HPLC method. Results： TLC spots clear and specific. A good linear relationship between peak area and concentration of forsythin was found at the range of 0.199 - 0.991 μg with a correlation coefficient of r = 0.999 9. The average recovery of forsythin was 99.7 % and RSD was 0.48 % （ n = 5 ）. Conclusion： The method is reliable, accurate and specific. It can be used for the quality control of Yinqiaoshangfeng Capsules.