萸黄连赤石脂禹余粮汤对小鼠蓖麻油性腹泻及胃肠推进运动的影响

Effects of the Decoction of Yu-huanglian Chi-shizhi and Yu-yuliang on Diarrhea in Mice and on the Activities of Stomach and Intestines

目的:观察萸黄连赤石脂禹余粮汤抗小鼠实验性腹泻的的作用,并探讨其作用机理。方法:采用蓖麻油引起小鼠腹泻,以思密达为阳性对照药,观察记录给药6 h内各时段的腹泻次数;并观察其对小鼠墨汁胃肠推进率的影响。结果:与模型组比较,萸黄连赤石脂禹余粮汤的大、中、小剂量组和思密达组分别在1,2,4 h不同时段的平均腹泻次数显著减少,差异具有显著统计学意义(P<0.05);萸黄连赤石脂禹余粮汤中剂量组的墨汁胃肠推进率明显下降,差异具有显著统计学意义(P<0.05)。结论:萸黄连赤石脂禹余粮汤对小鼠蓖麻油性腹泻具有一定的防治作用,并且其抗腹泻作用与抑制胃肠推进运动有关。

Objective： To stuty the effect and mechanism of the decoction of Yu-huanglian Chi-shizhi and Yuyuliang on diarrhea in mice. Methods：Taking smectite powder as positive controlled medicine, we arose diarrhea of the mice by castor oil, and observed the drug＇s effect on ink-pushing of the stomach and intestines of the mice. Results： Compared with the untreated group, the average degrees of the diarrhea of the large dose group and middle dose group and the smectite powder group reduced obviously 1,2 and 4hours later. The difference has obvious statistics sense（ P 〈 0.05）. The ink-pushing rate in the stomach and intestines of the middle dose group of the decoction of Yu-huanglian Chi-shizhi and Yu-yuliang reduced obviously. The difference has obvious statistics sense（ P 〈 0.05）. Conclusions：The decoction of Yu-huanglian Chi-shizhi and Yu-yuliang has prevention and cure effect on diarrhea in mice induced by castor oil, and its effect of resisting diarrhea relates to restraining the movement of the stomach and intestines.