人皮质骨矿化基质中骨盐框架结构

The Frame Structure of Bone Minerals in Calcified Matrix in the Normal Human Bones

目的：研究人皮质骨矿化基质中骨盐的框架结构及框架中骨微间隙。方法：应用透射电镜、场发射扫描电镜观察、电脑图像分析及能谱分析，分析无骨病成人长骨、扁骨２００例骨盐分布特征。结果：骨盐框架结构由微柱、微梁、微小梁、弓状梁、致密点、隔板和骨微间隙构成。骨微间隙由洞、内衬和壁组成，洞平均直径为８４．４±７５．６ｎｍ，与骨小管相比有显著差异（Ｐ值＜０．００１），平均密度为１１～１７个／μｍ２，与骨小管之比超过１０：１。骨盐分针形结晶和微颗粒结晶。结论：骨盐框架结构及骨微间隙是骨盐在人皮质骨矿化基质中的存在形式，可能与骨盐吸收、沉着有关。

Object: To further prove and reaffirm the frame structure of human bone minerals and their related bone microspaces,which are less noticeable in calcified normal bone matrix. Materials and methods: Using transmission election microscopy, field emission electron microscopy, computerized image analysis , the characteristics of the distribution of the frame structure of bone minerals and the bone microspaces were defined in 200 human bone specimens. Results: The frame structure of bone minerals can be separated into six different grades , consisting of the micropillar, microbeam, microtrabecula, septal plate, arched trabecula and dense aggregation. Bone microspaces composed of the holes, lining, and their walls. The average diameter of the holes was 84.4± 75.6nm. The holes in comparion with canaliculi is grea significance (P<0.001). The average value of density in the bone mineral was 11￣17/μm 2. Bone microspaces/canaliculi ratio was 10:1. The bone minerals can be classified as the needle and the microgranule shaped ones. Conclusions: The frame structure of bone minerals and the microspaces exist so widely that in the calcified matrix , they definitely play a crucial role both in bone mineral absorptions and depositions.