加替沙星治疗急性细菌感染86例

Observation of Curative Effect of Gatifloxacin in Treatment of Acute Bacterial Infections of 86 Cases

目的评价加替沙星治疗急性细菌性感染的有效性和安全性。方法采用随机对照多中心平行开放的试验设计,将152例呼吸系统、泌尿系统及皮肤软组织感染患者随机分为A组(86例)和B组(66例),A组静脉滴注加替沙星(200mg,每12h一次,B组静脉滴注左氧氟沙星(200mg,每12h一次),疗程均为7～14d。结果A组和B组临床有效率分别为86.05%(74/86)和81.82%(54/66),细菌清除率分别为89.19%(66/74)和75.00%(42/56),细菌药物敏感试验敏感率分别为78.38%(58/74)和67.86%(38/56),均未发现明显不良反应。结论加替沙星治疗细菌所致的呼吸系统、泌尿系统及皮肤软组织感染安全有效。

Objective To evaluate the curative effect and safety of gatifloxacin in the treatment of acute bacterial infections. Methods A randomized comparative open multicenter trial was conducted. 152 patients with bacterial infections of respiratory system, urinary system and skin soft tissues were randomly divided into Group A （86 cases） and Group B （66 cases）. Group A were treated with gatifloxacin injection 200 mg, intravenous drip, q. 12 h; Group B were treated with levofloxacin injection 200 mg, intravenous drip, q. 12 h. The course of treatment for both groups was 7- 14d. Results The overall clinical effective rates of Group A and Group B were 86.05% （74/86） and 81.82% （54/66） respectively （ P 〉 0.05）; the bacterial clearance rates of the 2 groups were 89. 19% （66/74） and 75.00% （42/56） respectively （ P 〈 0. 05）; the bacterial susceptible rates of the 2 groups were 78.38% （58/74）, 67.86% （38/56） respectively （ P 〈 0.05）. No adverse effects were found in both groups. Conclusion Gatifloxacin injection is effective and safe in the treatment of bacterial infection of respiratory system, urinary system and skin soft tissues.