摘要
目的:探讨慢性乙型肝炎(CHB)患者血清HBV-DNA载量与临床及肝组织病理的关系。方法:测定70例CHB患者血清ALT、TBIL、HBV-DNA载量,同时行肝活体组织检查,对肝脏进行炎症分级和纤维分期。结果:(1)血清HBeAg阳性组HBV-DNA定量水平明显高于HBeAg阴性组,血清HBV-DNA载量与HBeAg的表达有显著相关性(t=3.98 P<0.001);(2)HBV-DNA载量与肝损害程度不存在明确的相关性(F=1.1 P>0.05);(3)慢性乙型肝炎血清HBV-DNA载量与肝功能ALT、TBIL不存在明确的相关性(P>0.05);(4)肝脏病理炎症分级G1、G2、G3、G4之间及纤维化分期S1、S2、S3、S4之间和HBV-DNA载量比较无统计学差异(P>0.05)。结论:血清HBV-DNA载量与HBeAg的表达有显著相关性,HBV-DNA载量与肝功能ALT、TBIL及肝损害程度没有必然的联系,与肝组织病理炎症分级及纤维化分期无明显相关性。
Objective:To investigate the relationship between the HBV DNA load and clinical or liver pathology in patients with chronic hepatitis B. Methods: Seventy the lael of serum ALT, bilirubin, HBV DNA load were detected and liver biopsy was done liver inflammation grade and fiber phases in 70 CHB patients. Results: (1) The HBV DNA level of HBeAg positive group was significantly higher to get than that of HBeAg-negative. The expression of serum HBeAg was significantly correlated with the HBV DNA load (t = 3.98,P〈0. 001) ; (2) There was no clear correlation between the HBV DNA load and the degree of liver damage (P〉0. 05) ; (3) There was no clear correlation between the HBV DNA load and serum ALT, bilirubin (P〉0.05 P〉0.05) ; (4) The HBV DNA load was not significant deviation between liver inflammation grade G1、G2、G3、G4 and fibrosis S1、S2、S3、S4 (P〉0. 05). Conclusion: Serum HBV DNA load have significant correlation with the expression of HBeAg, but nothing to do with ALT, bilirubin, histopathological grading and staging of hepatic fibrosis.
出处
《中国临床医学》
北大核心
2007年第3期337-338,共2页
Chinese Journal of Clinical Medicine