绝经后女性冠心病患者性激素水平与胰岛素抵抗的相关性

Relationship between Sex Hormone Level and Insulin Resistance in Postmenopausai Women with Coronary Heart Disease

目的:探讨绝经后女性冠心病患者性激素水平的变化及与胰岛素抵抗(IR)的关系。方法:检测30例绝经后女性冠心痛患者和30例正常对照组的血清雌二醇(E2)、睾酮(T)、孕酮(P)、促卵泡激素(FSH)、促黄体生成素(LH),水平和空腹血糖(FPG)、葡萄糖耐量试验2 h血糖(2 h PG),空腹胰岛素(FIN),计算胰岛素敏感指数(ISI)及E2/T值,用t检验,并将冠心病患者E2、E2/T与血糖、FIN、ISI作线性相关分析。结果:与对照组比较,绝经后女性冠心病患者E2、ISI显著降低(P<0.01);FPG、2 h PG、FIN显著增高(P<0.05);T、P、FSH、LH无显著差异(P>0.05)。相关分析表明,E2、E2/T与FIN呈显著负相关而与ISI呈显著正相关(P<0.05)。结论:提示绝经后女性高胰岛素血症和IR与雌激素水平降低、E/T比例失调有关,它们共同参与绝经后女性冠心病的发生和发展。

Objective：To study sex hormone levels in postmenopausal women with coronary heart disease （CHD） and the relationship between sex hormone level and insulin resistance （IR）, Methods：The level of estradiol （E2） , testosterone （T）, pregnendione（P）, follicle stimulating hormone （FSH）, luteinizing hormone（LH）, fasting blood glucose（FBG）,Oral glucose tolerance test 2 h glucose （2 hPG）, fasting insulin（FIN）, insulin sensitivity index （ISI） and E2/T ratio were measured in 30 postmenopausal women with CHD and 30 controls. Linear correlation was analyzed between E2,E2/T and FIN, ISI. Results：The results showed that the concemtraion of E2, ISI were decreased （P〈0.05） and FBG, 2 hPG, FIN were elevated （P〈0.05） in postmenopausal CHD women. But the concentraion of T, P, FSH and LH didn＇t charge significantly （P〉0.05）. There were significant negative correlation between E2 and FIN, also between E2/T ratio and FIN There were significant positive correlation between E2 and ISI, also between E2/T ratio and ISI （P〈0.05）. Conclusion：There is a close relationship between insulin resistance and sex hormone disorder in postmenopausal women . Both play an important role in the development of CHD.