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人白细胞抗原、人乳头瘤病毒感染与宫颈癌相关性的研究进展 被引量:4

Advance in the Correlation among Human Papillommarirus Infection and Cervical Cancer
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摘要 宫颈癌的发生是一个多因素、多阶段的渐进过程.目前认为,人乳头瘤病毒(HPV)感染正常宫颈鳞状上皮是宫颈癌的始发因素,但是,特异性的HPV感染并不是宫颈癌发生的唯一致病因素.目前认为,浸润癌的发生需要经历一段漫长的宫颈上皮内瘤样变(CIN)过程,根据其组织病理变化分为CINⅠ、CINⅡ和CINⅢ3个级别.大部分CINⅠ病变,特别是未经过治疗的年轻妇女,有50%~60%的患者可以自然消退,剩余的才会进展成为CINⅡ/Ⅲ.由癌前期病变到浸润癌的变化约需要8~10年,甚至20年,在这段较长的潜伏期中,被感染宿主基因突变、环境中其他因素的作用均对宫颈癌的发生发展有重要影响.
出处 《中国临床医学》 北大核心 2007年第3期377-379,共3页 Chinese Journal of Clinical Medicine
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参考文献13

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同被引文献19

  • 1林贞花,柳明沫,赵祎玮,吴群英,刘双平,金仁仙.人乳头状瘤病毒阴性的宫颈癌及其癌前病变中p16^(INK4A)蛋白表达和DNA倍体分析[J].中华病理学杂志,2006,35(7):412-416. 被引量:13
  • 2宁军,龚浩.中晚期肿瘤患者T淋巴细胞和NK细胞检测的临床意义[J].实用全科医学,2007,5(7):587-588. 被引量:12
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