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人白细胞抗原、人乳头瘤病毒感染与宫颈癌相关性的研究进展 被引量：4

Advance in the Correlation among Human Papillommarirus Infection and Cervical Cancer
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摘要 宫颈癌的发生是一个多因素、多阶段的渐进过程.目前认为,人乳头瘤病毒（HPV）感染正常宫颈鳞状上皮是宫颈癌的始发因素,但是,特异性的HPV感染并不是宫颈癌发生的唯一致病因素.目前认为,浸润癌的发生需要经历一段漫长的宫颈上皮内瘤样变（CIN）过程,根据其组织病理变化分为CINⅠ、CINⅡ和CINⅢ3个级别.大部分CINⅠ病变,特别是未经过治疗的年轻妇女,有50%～60%的患者可以自然消退,剩余的才会进展成为CINⅡ/Ⅲ.由癌前期病变到浸润癌的变化约需要8～10年,甚至20年,在这段较长的潜伏期中,被感染宿主基因突变、环境中其他因素的作用均对宫颈癌的发生发展有重要影响.
作者 姜波玲 肖长义
机构地区 湖北三峡大学医学院
出处 《中国临床医学》 北大核心 2007年第3期377-379,共3页 Chinese Journal of Clinical Medicine
关键词 人乳头瘤病毒感染 宫颈癌发生 人白细胞抗原 癌相关性 宫颈上皮内瘤样变 癌前期病变 宫颈鳞状上皮 CINⅠ
分类号 R752.53 [医药卫生—皮肤病学与性病学]
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参考文献13

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同被引文献19

  • 1林贞花,柳明沫,赵祎玮,吴群英,刘双平,金仁仙.人乳头状瘤病毒阴性的宫颈癌及其癌前病变中p16^(INK4A)蛋白表达和DNA倍体分析[J].中华病理学杂志,2006,35(7):412-416. 被引量：13
  • 2宁军,龚浩.中晚期肿瘤患者T淋巴细胞和NK细胞检测的临床意义[J].实用全科医学,2007,5(7):587-588. 被引量：12
  • 3Parkin D,Bray F,Ferlay J ,et al. Estimating the world cancer burden:globocan 2000[J].Int J Cancer,2001,94:153.
  • 4Park TC,Kim CJ,Koh YM,et al. Human papillmoma virus genotyping by he DNA chip in the cervical neoplasia[J]. DNA Cell Biol, 2004,23 (2):119.
  • 5Santos AL, Derchain SF, Martins MR,et al. Human papillomavirus viral load in predictinghigh-grade CIN in women with cervical smears showing only atypicalsquamous cells or low-grade squamous intraepithelial lesion[J]. Sao Paulo Med J, 2003, 121 (6) :238-243.
  • 6Bar-Am A, Gamzu R, Levin I,et al. Follow-upby combined cytology and human papillomavirus testing for patientspost-cone biopsy: results of a long term follow-up[J]. Gynecol Oncol,2003, 91(1):149-153.
  • 7Szoke K, Sapy T, Krasznai Z, et al. Moderate variation of the oncogenicpotential among high-risk human papillomavirus types ingynecologic patients with cervical abnormalities[J]. J Med Virol,2003,71(4) :585- 592.
  • 8Howard M, Sellors, Kaczorowsli J. Optimizing the hybrid capture Ⅱ human papillomavirus test to detect cerrical in-traepit helial neoplasia[J]. Obstet Gynecol,2002,100 (5 Pt 1) :972.
  • 9Guo M, Sneige N, Silva EG, et al. Distribution and viral load of eight oncogenic types of human papillomavirus (HPV) and HPV 16 integration status in cervical intraepithelial neoplasia and carcinoma[J]. Mod Pathol, 2007, 20:256-266.
  • 10Lin Z, Shen X. Jin Z, et al. HPV genotyping by oligonucleotide microarray and p16^INK4A expression in the uterine cervical intraepithelial neoplasm and invasive carcinoma in Korean women[J]. Pathol Int, 2005, 55(8): 491-496.

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中国临床医学
2007年 第3期

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