共混合聚(醚-酯)多嵌段共聚物的表面表征及其血液相容性研究

SURFACE CHARACTERIZATION OF BLENDED POLY(ETHER-ESTER) MULTIBLOCK COPOLY-MER AND ITS BLOOD COMPATIBILITY

本文通过X-射线光电子能谱(XPS)、表面接触角、表面ξ电位和血液相容性实验,研究了聚(醚-酯)多嵌段共聚物及其共混物的表面组成和性质与血液相容性的关系。实验结果表明,疏水性的PET-PTMO多嵌段共聚物的血液相容性很差,并且与表相中软段的富集量无关;当亲水性的PET-PEO多嵌段共聚物与疏水性的PET-PTMO多嵌段共聚物共混后,发现存在着一个最佳的共混比例,此时材料表面的血小板粘附量大大降低。对于共混物,表相△[C—O)/[C—O]和表面ξ电位可以较好地与血小板粘附量相关联。以上结果清楚地表明,材料表面的亲-疏水性平衡、软段深度层次分布及表面电位是影响血液相容性的重要因素。

By using X-ray photoelectron spectroscopy (XPS), surface contact angle, surface potential and blood compatibility, the relationship between the composition and property of the surface and the blood compatibility of poly (ether-ester) multiblock copolymer and its blend has been studied. Experimental results indicated that the blood compatibility was very bad and bore no relation to the enrichment of PTMO soft segment in the surface phase for hydrophobic PET-PTMO multiblock copolymers. In the mixture of hydrophobic PET-PTMO and hydrophilic PET-PEO, an optimum blended proportion was found. The platelet adhering to the material surface conside-rably decreased at the optimum.and surface potential couldbe better correlated with the blood compatibility in the blends. The above results showed clearly that the hydrophilic and hydrophobic balance, the distribution of the soft segment in the depth and potential of the material surfaces were important factors affecting blood compatibility.