含有二个聚醚软链段的聚醚聚酯嵌段共聚物的合成及其血液相容性的研究

THE STUDY OF SYNTHESIS AND BLOOD COMPATIBILITY OF POLYETHER POLYESTER BLOCK COPOLYMER CONSISTING OF TWO POLYETHER SOFT SEGMENTS

本文报道了一类新的具有二种聚醚软链段(PTMGT和PEGT)和一种聚酯硬链段(PET)的混合聚醚-聚酯嵌段共聚物(MPEE)的合成和它的血液相容性,并与具有相同软、硬链段比及相同软链段组成比(PTMGT/PEGT)的二种聚醚聚酯嵌段共聚物(PTMGT-PET和PEGT-PET)的共混物(BPEE)的性质进行了比较,结果表明:(1)聚醚聚酯嵌段共聚物的血液相容性可以通过引入亲水性好的PEGT组分而得到提高;(2)在多数的组成比下,共聚型的MPEE具有比共混型的BPEE优良的血液相容性;(3)特定的组成比:PTMGT/PEGT=60/40(mol),共混型的BPEE:(60/40)呈现最好的血液相容性以及最佳的力学性质。研究中发现材料的微相分离结构同血液相容性有关,细微的相分离结构可导致优良的血液相容性。

In the present paper a new type of polyether polyester block copolymer (MPEE) consisting of two components of polyethers (PTMG and PEG) as soft segment component has been synthesized. And it has been also investigated in comparison with blended polyether polyester block copolymer (BPEE) consisting of the same composition ratio of hard and soft segments and both two polyethers (PTMG and PEG), It was found that: (1) Improvement of blood compatibility of polyether polyester block copolymer can be achieved by introducing hydrophilic component PEG into it; (2) Generally the blood compatibility of MPEE type is better than that of BPEE; (3) Under a specific molar ratio of PTMGT-PET to PEGT-PET (60/40) the blended copolymer (BPEE 60/40) shows the best blood compatibility, as well as mechanical property. This might be related to more tiny microphaseseparated structure. The relationship between blood compatibility and structure of copolymer has been discussed.