小儿松果体区肿瘤的治疗

The strategies of treatment for the children pineal region tumors

目的探讨小儿松果体区肿瘤的治疗策略。方法对43例患松果体区肿瘤病例施以立体定向放射外科、全脑放疗为主,化疗、Ⅴ-P术、手术切除为辅助的治疗方略,以探讨疗效。结果随访3～44个月,平均22.6个月,肿瘤消失25例,缩小11例,不变5例,增大2例,无死亡病例。肿瘤控制率95.3%。结论采取以立体定向放射外科、全脑放疗为主,化疗、手术切除为辅助的治疗策略,可以极大限度地降低手术造成的损伤,提高小儿松果体区肿瘤患者生存质量,延长生存期。

Objective To study the strategies of treatment for children pineal region tumors. Methods 43 children with pineal region tumors were firstly treated by stereotactic radiosurgery, whole brain radiation and secondary treated by chemotherapy, the operation of Ventricle-plexus coeliacus shunt and resection. Results 43 cases were followed up for 3 to 44 months （ mean 26.6 months ） , the tumors disappeared in 25 cases, shrank in 11 cases, invariability in 5 cases, enlarged in 2 cases. The tumor were controlled in 95.3%. No death case. Conclusions Stereotactic radioneurosurgery, whole brain radiation, chemotherapy, combined by Ⅴ-P shunt and resection will reduce the impairment of operation, increase life quality and prolong survival time.