多嵌段聚醚-酯共混物的微相结构与血液相容性研究

STUDY ON THE RELATIONSHIP OF MICROSTRUCTURE AND BLOOD COMPATIBILITY OF MULTIBLOCK POLYET HER-ESTER BLENDS

本工作合成了两种性质不同的聚醚-酯多嵌段共聚物,一种是以聚对苯二甲酸乙二酯为硬链段,聚乙二醇(PEGT)为软链段的亲水性多嵌段共聚物,另一种是以聚对苯二甲酸乙二酯为硬链段,聚四亚甲基醚二醇(PTMGT)为软链段的疏水性多嵌段共聚物。将两种共聚物以一定的比例共混,制备多嵌段聚醚-酯共混物。 改变共混物的组成,研究其微相结构与血液相容性的关系。采用动态力学谱(VES)、示差扫描量热(DSC)、透射电镜(TEM)和扫描电镜(SEM)等测定共混物的微观结构,采用微球柱法评价共混物的血液相容性。实验结果表明:材料的微观非均相结构及亲水平衡是决定血液相容性的重要因素。

Two kinds of multiblok poly (ether-ester) copolymers with different properties have been synthesized. One of them consisted of poly (ethylene terephthalate) as hard segment and poly-(ethylene glycol) (PEGT), as hydrophilic soft segment while, another consisted of poly(ethy-lene terephthalate) as hard segment and poly (tetramethylene glycol) (PTMGT) as soft segment,, which is a relatively hydrophobic one.Relationship between the microstructure and blood ooknpatibility has been observed by changing the composition of blends. Microphase separated structure of blends has been determined by means of VES. DSC, SEM and TEM. Blood compatibility of the blends was evaluated by column beads method. The experimental results indicate that microphase separated structure and hydrophilic-hydrophobic balance of materials are important factors which affect the compatibility of these materials with blood.