196例鼻咽癌患者疗效分析

The analysis of the treatment outcomes of 196 patients with nasopharyngeal carcinoma treated by radiotherapy

目的:回顾性分析鼻咽癌治疗疗效,并分析影响预后的因素。方法:对在我科接受根治性放射治疗的196例鼻咽癌患者进行随访,所有患者均接受6MV-X线照射,剂量范围64～80Gy。其中37例患者配合化疗,化疗方案均采用5-FU+DDP,化疗周期2～4周期。结果:全组患者5年和10年的总生存率分别为53.10%和39.90%。单因素分析发现,性别、临床分期、T分期、N分期、原发灶剂量和下颈淋巴引流区剂量是影响预后的因素。多因素分析仅提示临床分期明显影响预后。结论:鼻咽癌放射治疗的疗效确切,临床分期、T分期、N分期是影响预后最主要的因素,提高早期患者的检出率是提高治疗鼻咽癌疗效的关键。

Objective： To analyze the results of nasopharyngeal carcinoma treated by radical radiotherapy, and explore the prognostic factors of patients. Methods： One hundred and ninty six patients with nasopharyngeal carcinoma who were treated in our department were analyzed retrospectively. All patients were irradiated with 6-MV photons and the total dose rang was 64-80Gy. Only 37 patients received additional chemotherapy. Results：The 5-year and 10-year overall survival rates were 53. 10% and 39. 90% , respectively. Single factors analysis showed that sex, clinical stage, T-stage, N-stage, dose of primary lesions and dose of low neck were prognostic factors; Multivariate analysis revealed that only clinical stage was independent factors for overall survival. Conclusion：The treatment results of nasopharyngeal carcinoma were confirmed, clinical stage, T-stage, N-stage were most important prognostic factors.