恶性实体瘤全身伽玛刀适形放疗643例报告

Clinical study of gamma ray whole body therapeutic system for malignant tumors(report of 643 cases)

目的:探讨全身伽玛刀治疗恶性实体瘤的应用价值。方法:对各种途径确诊的643例恶性实体瘤患者行全身伽玛刀治疗,在全身伽玛刀定位系统下以5～7mm薄层CT连续扫描靶区,根据三维重建图像资料,确定治疗方案,小靶区50%剂量线处5～10Gy/次,40～50Gy/4～10次;中靶区50%剂量线处4～8Gy/次,48～56Gy/6～14次;大靶区40%～50%剂量线处3～4Gy/次,40Gy/10～14次后缩野,追加剂量10～30Gy,在2～3周内完成治疗,1～3个月复查,比较前后的症状及肿瘤大小。结果:全身伽玛刀靶向治疗后,肿瘤完全缓解39.2%,部分缓解55.4%,无变化5.1%,进展0.3%,临床症状缓解或消失。结论:全身伽玛刀靶向适形放疗是恶性实体瘤控制局部病灶,提高肿瘤患者生存质量的有效手段。

Objective：To evaluate the feasibility of whole body γ-radiation system （γ-knife） in the treatment of malignant tumors. Methods：Six hundred and forty three patients were diagnosed by pathology or cytology, were treated with gamma ray whole body therapeutic system（ body γ-knife）. They received a total dose from 40-60Gy/2-3w, 3-10Gy/fraction, 5 fractions/week. Results： The response rate was 94. 6% , with complete remission 39. 2% , partial remission 55.4% , no remission 5.1% , and tumor progression 0. 3%. Conclusion：Whole body γ-radiation system（γ-knife） is an effective method of treatment in patients with malignant tumors.