万托林及普米克令舒治疗儿童哮喘急性发作的疗效观察

Clinical effect of ventolin combined with pulmicort in the treatment of children with acute exacerbation of asthma

目的观察万托林及普米克令舒雾化吸入治疗儿童哮喘急性发作的疗效。 方法将85例儿童哮喘患儿随机分为观察组（55例）和对照组（30例），两组均在祛除病因、抗感染的基础上，观察组给予万托林、普米克令舒联合雾化吸入；对照组则给予氨茶碱、琥珀酸氢化考的松治疗。24h后观察两组患儿哮喘缓解、呼气峰流速（PEF）的改善情况。 结果观察组55例患儿中哮喘临床控制38例（69．1％），显效10例（18，2％），好转6例（10．9％），无效1例（1，8％），总有效54例（98．2％）；对照组30例中哮喘控制14例（46．7％），显效6例（20．0％），好转4例（13．3％），无效6例（20．0％），总有效24例（80．0％）。两组总有效率比较有显著性差异（P〈0．05）。 结论万托林及普米克令舒雾化吸入能明显改善患儿的肺功能，使哮喘急性发作得到缓解，且安全性好，方法简便，为一种有效的治疗方法。

Aim To observe the effect of atomizing inhalation of ventolin combined with pulmicort in the treatment of children with acute exacerbation of asthma. Methods 85 cases with asthma were randomized into two groups： 55 cases in the observing group and 30 in the control group. On the basis of eliminating causes and anti-infection, the cases in the observing group underwent atomizing inhalation of ventolin combined with pulmicort, while the cases in the control group were treated with aminophylline, hydrcortisone sodium succinate. The relief of asthma and the improvement of PEF were observed 24 hours later. Results In the observing group, the clinical symptom of 38 cases （69.1%） was controlled, 10 cases （18.2%） markedly improved; 6 cases （ 10. 9% ） improved; 1 case （1.8%） no effect and the total effective rate was 98.2%, while in the control group, 14cases （46. 7% ） markedly improved; 4cases （13.3%）improved; 6cases （20. 0% ） no effect; and the total effective rate was 80. 0%. There was significant difference in the two groups （ P 〈 0. 05 ）. Conclusion The treatment of atomizing inhalation of ventolin combined with pulmicort can significantly improve the function of lungs, relieve the acute exacerbation of asthma, which is safe, convenient and effective as well.