摘要
以2,6-二氯嘌呤和1,2,3,5-四乙酰核糖为原料,四氯化锡为催化剂,130℃下反应18min,得到中间体2,6-二氯嘌呤-2',3',5'-三乙酰基核苷。该中间体在硫酸-甲醇中脱酰基得到2,6-二氯嘌呤核苷,为白色粉状结晶,收率63%,纯度(HPLC)≥99.0%,熔点152￣154℃。
A new method for synthesizing 2,6-dichloroadenosine was reported in the paper. The starting material 2,6- dichloropurine was condensed with 1,2,3,5-tetraacetylribofuranose at 130℃ for 18 minutes to form 2＇, 3＇, 5＇-triacetyl- 2,6-dichloroadenosine, which was deprotected in H2SO4-CH3OH at 0 -5℃ to give the target product 2,6- dichloroadenosine as a white crystalline powder. The yield was 63%, purity （HPLC） ≥ 99.0%, and the melting point of the product was 152-154℃.
出处
《精细化工中间体》
CAS
2007年第3期35-37,共3页
Fine Chemical Intermediates
基金
国家自然科学基金资助项目(20372018)。
