辛伐他汀对急性脑梗死患者脑梗死体积变化的影响及疗效分析

STUDY THE EFFECT OF SIMVASTATIN ON THE CHANGES OF INFARCTION TISSUE VOLUME IN ACUTE CEREBRAL INFARCTION

目的观察辛伐他汀对急性脑梗死患者的干预治疗及脑梗死体积变化的影响。方法将120例急性脑梗死患者随机分为治疗组和对照组,各60例,治疗组用辛伐他汀20mg/d口服,对照组仅使用常规治疗,15d为一疗程。一疗程后比较两组显效率、总有效率及脑梗死体积。结果治疗组和对照组显效率分别为63.3%和43.3%(p<0.05),总有效率分别为88.8%和66.7%(p<0.05)。治疗组与对照组比较,脑梗死体积明显缩小(p<0.05)。结论辛伐他汀有明显改善急性脑梗死患者疗效及缩小脑梗死体积的作用。

Objective To investigate the effect of simvastatin on intervening patients with acute cerebral infarction （ACI） artd the changes of volume of infarction tissue. Methods 120 patients with ACI were randomized into two groups ： the treatment group receiving 20 mg/d simvastatin （ n = 60） and the control group receiving routine therapy for 15days, the response rate, total efficacy rate and infarction tissue volume of two groups were compared. Results The response rates of two groups were 63.3% and 43.3% , respectively （p 〈 0.05 ）. Total efficacy rates were 88.8% and 66.7% （p 〈0.05）. The volume of infarction tissue in treatment group was significantly decreased as compared with control group（p 〈 0. 05）. Conclusion Simvastatin can distinctively improve curative effect of acute cerebral infarction and dwindle the size of cerebral infarction tissue.