血清心肌肌钙蛋白T和高敏C反应蛋白在糖尿病并发心肌病早期诊断中的应用

The application of serum cardiac troponin T and high sensitive c-reactive protein in early diagnose of diabetes patients complicated with myocardiopathy

目的观察糖尿病患者血清心肌肌钙蛋白T(cTNT)和高敏C反应蛋白(hs-CRP)水平与糖尿病并发心肌病的关系。方法将糖尿病患者分为3组:血糖控制良好组26例;血糖控制不好但无心肌病并发症患者39例及并发心肌病患者31例及健康体检者25例。结果血糖控制良好组血清hs-CRP水平较正常对照组明显增高,但cTNT水平差异无显著性;血糖控制不好并发心肌病组及无并发心肌病组cTNT水平和hs-CRP水平均较血糖控制良好组明显增高;并发心肌病组cTNT水平和hs-CRP水平较无并发心肌病组增高明显。结论血糖控制良好会明显降低并发心肌病;cTNT和hs-CRP的联合检测有助于糖尿病并发心肌病的早期诊断。

Objective To observe the levels of serum cardiac troponin T（cTNT） and high sensitive C-reative protein in diabetes mellitus（DM） patients and the relationship between cTNT and hs-CRP and diabetes with myocardiopathy. Methods The patients with DM were divided into there groups： 26 patients with normal glucose; 39 patients with high glucose and without myocardiopathy;31 patients with high glucose and with myocardiopathy; 25 healty physical exammation persons. Results The levels of hs-CRP in the patients with normal glucose were significantly higher than the healty group, but the levels of cTNT were no differences; the levels of hs-CRP and cTNT in the patients with high glucose were significantly higher than patients with normal glucose; the levels of hs-CRP and cTNT in the patients with diabetic myocardiopathy were significantly higher than without myocardiopathy. Conclusion If the glucose is in normal, the incidence of diabetic myocardiopathy will obviously decline; the cTNT and hs-CRP de- termination may be a sensitive marker in early detecting myocardiopathy in diabetes mellitus.