中关村地区1984—2000年出血性脑卒中和缺血性脑卒中发病率变化趋势及病因因素探讨

Analysis of Morbidity Tendency and Research the Etiological Factor of Hemorrhagic Apoplexy and Cerebral Arterial Thrombosis from 1984 to 2000 in Zhongguancun area

目的评估北京中关村地区人群1984—2000年16年间出血性脑卒中及缺血性脑卒中发病率变化趋势,探索脑卒中危险因素的线索。方法采用北京MONICA监测方案及后续研究资料,按其统计方法,用2000年全国人口年龄构成比计算标化发病率,并分析性别、年龄别在监测初、中、末期发病率变化。结果(1)中关村地区1984—2000年脑卒中年平均发病率男性378.16/10万大于女性209.95/10万(P<0.01)。(2)女性脑卒中发病率、标化发病率呈下降趋势(P<0.05)。(3)人群缺血性脑卒中年平均发病率251.33/10万大于出血性脑卒中年平均发病率41.47/10万(P<0.01)。(4)两型脑卒中发病率随年龄增大而上升(P<0.01)。(5)人群血清胆固醇水平1984与1993年相比个别年龄组呈上升(P<0.05)。结论中关村地区脑卒中防治重点是中老年人群缺血性脑卒中,人群血清胆固醇水平变化是病因因素中监测重点。

OBJECTIVE To evaluate the morbidity tendency of hemorrhagic apoplexy and cerebral arterial thrombosis from 1984 to 2000 in Zhongguancun area and to explore the risk factor of cerebral apoplexy. METHOD Use MONICA statistical method to calculate the standardized morbidity and analyze the diversity of sexuality or age in different monitoring stages with the population pyramid ratio during 2000 in China, MONICA monitoring program and subsequent research data. RESULT （1） The annual mean morbidity of male which is 378.16/0.1 million is larger than 209.05/0.1 million of female from 1984 to 2000 in Zhongguancun area （P〈0.01）. （2） The morbidity and standardized morbidity of cerebral apoplexy is descent in female （P〈0.05）. （3） The annual mean morbidity of cerebral arterial thrombosis which is 251.33/0.1 million is larger than 41.46/0.1 million of hemorrhagic apoplexy （P〈0.01）. （4） The morbidity of this two types increase as the ageing. （5） The level of serum cholesterol has increased from 1984 to 1993 in several groups （P〈0.05）. CONCLUSION The most important point of prevention and cure in Zhongguancun area is cerebral arterial thrombosis of aged people, the tendency of cholesterol level will be the emphasis of etiopathogenisis monitoring. address