黛力新辅助治疗质子泵抑制剂治疗无效的非糜烂性反流病

Auxiliary therapy with Deanxit in patients of non-erosive reflux disease non-responding to proton pump inhibitor

目的观察黛力新辅助治疗质子泵抑制剂治疗无效的非糜烂性反流病(NERD)的疗效。方法64例患者按就诊顺序随机分为两组,对照组32例予雷贝拉唑10mg,每日2次;法莫替丁40mg,每晚1次。治疗组32例在对照组治疗基础上加用黛力新1粒,每天早上、中午各1次,治疗4周后进行疗效对比。结果治疗组总有效率81.3%,明显优于对照组62.5%(P<0.05)。结论黛力新辅助雷贝拉唑、法莫替丁对质子泵抑制剂治疗无效的非糜烂性反流病有效。

Objective To observe the effectiveness of auxiliary therapy with Deanxit in patients of non-erosive reflux disease （NERD） who did not respond to proton pump inhibitor. Methods Sixty four NERD patients were randomly divided into two groups： the treatment group （n=32） and control group （n=32）. Patients in control group were given with Raheprazole 10mg twice a day, Famotidine 40mg every night. Patients in the treatment group were given the same drugs plus Deanxit （one tablet every morning and noon）. The clinical outcomes of two groups were compared after 4 weeks. Results The effective rate in treatment group was 81.3%, while that was 62.5% in control group （P〈0.05）. Conclusion Auxiliary therapy of Deanxit combined with Rabeprazole and Famotidine is effective to NERD patients who did not respond to proton pump inhibitor.