高压氧治疗对脑梗死患者血清神经元特异性烯醇化酶的影响

The effect of hyperbaric oxygen treatment on neuron-specific-enolase levels in patients with acute ischemic stroke

目的为观察脑梗死后血清神经元特异性烯醇化酶的动态变化,以及高压氧治疗后血清NSE的变化,判断高压氧治疗脑梗死的疗效。方法将脑梗死患者84例,随机分为高压氧治疗组42例,常规治疗组42例,分别测定发病第1、2、3、12天的血清NSE水平,采用50例健康老年人的血清NSE作为正常对照组。结果脑梗死患者血清NES水平明显高于正常组,P<0.01,HBO治疗组第2、3、12天血清NSE水平与常规治疗组相比有显著差异,(第2天P<0.05,第3天,第12天P均<0.01)。结论NSE可以作为反映脑梗塞患者脑细胞损伤程度的生化指标,早期高压氧治疗有助于减轻脑梗死病情。

Objective To investigate the effect of hyperbaric oxygen （HBO） treatment on neuron-specific-enolase （NSE） levels in patients with acute ischemic stroke. Methods Eighty four patients with acute ischemic stroke were divided into two groups randomly： HBO treatment group and general treatment group, 42 cases in each. Serum levels of NSE were measured in all patients on d 1, 2, 3, 12, and 50 healthy elderly subjects as controls. Results The serum level of NSE in acute ischemic stroke sufferers was higher than that of normal controls （P〈0.01）. The serum level of NSE in HBO group was markedly lower than that of general treatment group on d2, 3, 12 （P〈0.05）. Conclusion NSE can be used as an indicator for brain cell damage, the HBO treatment can alleviate the brain damage induced by acute ischemic stroke effectively.