摘要
采用叔丁氧羰基(BOC)对2-氨基乙腈的氨基进行保护,在氨气的甲醇溶剂中催化形成脒,最后用无水溴化氢脱保护得到最终产物2-氨基乙脒化二溴化氢盐,经核磁鉴定为目标产物。
Treatment of 2-aminoacetonitinle with di-tert- butyldicarbonate gave N-BOC-2-aminoacetonitrile, which was then catalyzed in the presence of ammonia and methanol to form amidine. The resultant 2-amino-acetamidine dihydrobremide was obtained after removal of the block groups with anhydrous hydro- bromide. Its structure was verified by 1HNMR.
出处
《化学试剂》
CAS
CSCD
北大核心
2007年第7期439-440,共2页
Chemical Reagents
