人体牙髓感觉功能昼夜节律性的增龄性变化

The Influence of Age upon Circadian Rhythm of Human Pulp Sensibility

目的探讨人体牙髓感觉昼夜节律的增龄性变化,以指导牙体牙髓疾病的诊断和治疗。方法在24h内7个等距间隔时间点,测定青年、中年、老年人下颌第一恒磨牙牙髓活力的阈值,运用Halberg余弦法分析各年龄组牙髓感觉功能的生物节律,并比较三者的差异。结果青年、中年、老年人牙髓感觉功能均具有近似余弦的昼夜节律变化,且三者昼夜节律性的整体变化趋势一致,感觉阈值的最高峰和最低谷分别出现在0∶00点与12∶00点。牙髓感觉阈值的中值和昼夜节律的振幅为青年>老年>中年。结论人体牙髓感觉功能昼夜节律性具有增龄性变化,从青年到中年,牙髓感觉阈值逐渐下降,并且牙髓感觉的昼夜波动幅度减小;从中年到老年,牙髓感觉阈值略有上升,昼夜波动幅度也略有增大。

Objective To explore the influence of age on the circadian rhythm of pulp sensibility, guide the diagnosis and treatment of dental and endodontic diseases. Methods The first lower molars of young, middleaged, and aged volunteers were inspected for the threshold of pulp sensitivity. Each inspection was implemented every 4 hours earlier, totally 7 times during 24 hours. All values of pulp sensibility threshold from each volunteer were analyzed by Halberg methods for cosinor-rhythmometry. The chronobiology characteristics of pulp sensibility were compared among young, middle-aged, and aged. Results The pulp sensibility threshold values of the young, middle-aged, and aged indicated to have the circadian rhythm alternation in period of 24 hours, with fitting well to a cosine curve. The trend of rhythm curve was similar to all three age groups. The acrophase and bathyphase appeared at 0：00 and 12：00 separately. The values and amplitudes of pulp threshold sensibility showed to be： young〉aged〉middle-aged. Conclusion The circadian rhythm of pulp sensibility changes according with age. The pulp sensibility threshold value is lower in aged people than in the young, and the lowest sensibility threshold is in middle-aged people. Besides, the extent of rhythm fluctuation is the least in middle-aged people.