肾上腺髓质素对大鼠肠系膜微血管和微淋巴管的作用

EFFECT OF ADRENOMEDULLIN ON MESENTERIC MICROVESSELS AND MICROLYMPHATICS IN RAT

应用活体显微电视录象技术，观察肾上腺髓质素（adrenomedullin，ADM）对大鼠肠系膜微血管和微淋巴管的作用及其对去甲肾上腺素（NE），内皮素（ET）作用的影响。结果表明，ADM直接扩张肠系膜各级微血管和微淋巴管，拮抗NE和ET引起的微血管效应及微循环血液流态的异常改变。ADM的上述作用可被一氧化氮生成抑制剂NG－nitro－L－arginine（L－NNA）显著抑制。

The dilatant effect of adrenomedullin (ADM), a novel peptide of 52 aminoacids, on the mesenteric microvessels and microlymphatics was investigated under microscopic observation. 10-6 mol/ L ADM could also ameliorate alteration of thehemorheology induced by 10-5 mol/L norepinephrine (NE) or 10-7 mol/L endothelin(ET). However, this ameliorative response was markedly inhibited in the presence ofNG-nitro-L-arginine (L-NNA), an inhibitor for production of nitric oxide