葛根素亚微乳的制备及家兔体内药物动力学评价

Preparation and Pharmacokinetics of Puerarin Submicron Emulsion in Rabbits

以复合物-相转变-高压乳化法制备葛根素亚微乳,检测其粒径、ζ电位、微粒形态和药物在亚微乳各相中的分布。以葛根素注射液为对照,评价该微乳在家兔体内的药物动力学。结果表明,制品平均粒径188.1nm,ζ电位(-29.1±1.3)mV;75.6%的葛根素分布在磷脂膜中。与葛根素注射液相比,其亚微乳的AUC、t1/2β增大,清除率减小。

Puerarin submicron emulsion was prepared by the complex-phase inversion-high pressure homogeneization technology. The particle size, ζ potential, morphology of submicron emulsion and drug distribution of the products were examined. The pharmacokinetic of puerarin submicron emulsion in rabbits were performed with puerarin injection as the control. The results showed that the mean diameter and ζ potential of submicron emulsion prepared were 188.1nm and （-29.1 ± 1.3）mV, respectively. The percentage of puerarin distributed in phospholipid membrane was 75.6 %. Compared with puerarin injection, the A UC and t1/2β of puerarin submicron emulsion increased, while the clearance rate of puerarin was decreased.