摘要
采用乳化蒸发-低温固化法制备了醋酸泼尼松龙固体脂质纳米粒,采用正交实验设计优化处方,并考察了理化性质。结果表明,所得制品呈类球状,粒径较均匀,平均粒径为(187±15)nm,载药量为4.8%,包封率79.4%。
Solid lipid nanoparticles （SLN） loaded with prednisolone acetate were prepared by the method of emulsification evaporation-solidification at low temperature. The formulation was optimized through orthogonal design. The physicochemical properties of SLN were investigated. The results showed that the products were spherical and well distributed. The mean diameter was （187±15）nm with drug loading of 4.8% and entrapment efficiency of 79.4 %, respectively.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2007年第7期499-501,共3页
Chinese Journal of Pharmaceuticals
关键词
醋酸泼尼松龙
固体脂质纳米粒
制备
prednisolone acetate
solid lipid nanoparticle
preparation
