虫蚁胶囊治疗慢性乙型肝炎疗效观察

The Effective Observation of Treating Chronic Hepatitis B Patients with Chongyi Capsule

目的:观察虫蚁胶囊治疗慢性乙型肝炎(CHB)患者的远期疗效。方法:将60例慢性乙型肝炎患者随机分为治疗组30例,对照组30例,治疗组服用虫蚁胶囊,对照组服用拉米夫定片,治疗12个月。于治疗前后及停药12个月后检测肝功能及乙肝病毒标志物的变化。结果:治疗结束后,两组均能明显改善患者的血清ALT、AST、GGT、ALB、GLB,其中治疗组升高ALB、降低GLB水平的作用优于对照组(P<0.05)。停药12个月后,治疗组在改善ALT、ALB、GLB方面优于对照组(P<0.05);治疗结束后,DNA阴转率对照组优于治疗组(P<0.05)。停药12个月后,对照组的DNA反跳率明显高于治疗组(P>0.05)。结论:虫蚁胶囊有降低慢性乙型肝炎患者HBVDAN含量,改善肝功能,远期疗效优于拉米夫定。

Objective ： To observe protensive efficacy of treating chronic hepatitis B patients with Chongyi capsule. Methods ： Sixty patients with chronic hepatitis B were divided into two groups at random： The patients of treatment group （ n =30） were treated by Chongyi capsule, and the patients of control group （ n =30） were treated by Lamivudine tablet, with one treatment period of 12 months. Liver function and HBV marker were measured before and after treatment, 12 months aftcr drug withdrwal. Result ： After treatment, the two groups could significautly improve ALT,AST,GGT, ALB, GLB in serum of patient, and increasing ALB and decreasing GLB in treatment group was better than control group （ P 〈 0.05 ） ; The improvement of ALT, ALB, GLB in treatment group were. better than control group （ P 〈 0.05 ）later 12 months drug withdrawal; After treatment, the rate of DNA negative in control group was better than treatment group（ P 〈0.05） ; The rate of DNA rebound in control group was higher than treatment group（ P 〉0.05）. Conclusion ： Through decreasing the HVBDNA of CHB patients, Chongyi capsule could improve liver function, which of protensive efficacy - better than that of Lamivudine tablet.