糖皮质激素性骨质疏松症研究述评

Discussion of Glucocorticoid osteoporosis

糖皮质激素(GC)已成为继发性雌激素缺乏、老年因素之后导致骨质疏松症的第3大原因。超生理剂量GC将引起骨生长抑制;长期应用GC会导致人体降钙素水平下降,因此GC可能通过降低降钙素的水平而间接促进骨吸收。GC对于体内激素水平及细胞因子的影响;GC对性激素、生长激素及降钙素的影响;GC对骨代谢有关细胞因子的影响;GC对0B的作用;GC对OC的作用。GC不是通过某一方面的单一因素诱发骨质疏松的,可能通过影响钙离子的代谢、内分泌系统、各种骨组织细胞功能及细胞因子活性等多方面的途径导致骨量丢失的。

Glucocorticoid（GC） has become the third mason to cause osteoporosis. The first is estrogenic hormonhunger, the second is senium. It is seemed that over physiological dose GC will cause bone growth inhibiting. If you use it too long, it can decrease the level of CT, so it can encourage the bone resorption indirectly. In tiffs article we wilt discus what GC will effect on SH, GH, CT,cell factors, OB and OC. GC cause osteoporosis is through effecting the metabolism of Ca^2＋ ,endocrine system, various kind functions of bone tissue cells, and the activities of cell factor.