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AMPA受体介导的突触可塑性与药物依赖 被引量：3

AMPA receptor-mediated synaptic plasticity and drug dependence
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摘要 突触可塑性改变是形成药物依赖长期效应的病理基础,兴奋性氨基酸受体在其中起十分重要的作用。近年来的研究表明,多种药物依赖过程与AMPA受体有关。联系药物依赖所致的AMPA受体的变化与神经元的可塑性改变,探讨AMPA受体介导药物依赖的形成机制,可为进一步理解AMPA受体在药物依赖中的作用提供帮助。 Change in synaptic plasticity is the pathologic foundation of drug dependence. AMPA receptor, a member of excitability amino acid receptors, plays an importance role in change of synaptic plasticity. Recent studies have demonstrated that AMPA receptor is involved in the development of drug dependence. This review summarizes the relationship between AMPA receptormediated synaptic plasticity and drug dependence.
作者 何建华 曹君利 曾因明
机构地区 江苏省肿瘤医院麻醉科 江苏省麻醉医学研究所、江苏省麻醉学重点实验室
出处 《国际麻醉学与复苏杂志》 CAS 2007年第3期224-227,共4页 International Journal of Anesthesiology and Resuscitation
关键词 药物依赖 AMPA受体 突触可塑性 drug dependence AMPA receptor synaptic plasticity
分类号 R74 [医药卫生—神经病学与精神病学]
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参考文献16

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  • 2Lee HK, Takamiya K, Han JS, et al. Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell,2003,112:631-643.
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国际麻醉学与复苏杂志
2007年 第3期

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