全身炎症反应与体外循环

Systemic inflammatory response and cardiopulmonary bypass

体外循环（CPB）可使机体产生大量的炎症介质,引起全身炎症反应综合征（SIRS）,进一步发展导致多器官功能障碍综合征（MODS）,其发病机制目前较为公认的是“二次打击”学说。围体外循环期SIRS的预防和治疗策略很多,CPB装置的改进及减少炎症介质的生成是主要措施。随着对核转录因子NF-kB研究的不断深入,有可能从分子生物学水平调控CPB引发SIRS的程度。

Cardiopulmonary bypass （CPB） induces excessive production of endogenous proinflammatory mediators, which are responsible for subsequent development of systemic inflammatory response syndrome （SIRS） and multiple organ dysfunction syndrome （MODS）. Improvement of CPB equipment and decrease in production of inflammatory mediators are the primary measures to prevent and treat SIRS. Inhibition of NF-KB activation may be beneficial for attenuating inflammatory response.