苦参素对实验性肝癌增生细胞核抗原和白细胞的影响

The Effect of Kurarinone on PCNA and WBC in Liver Cancer Animal Model

目的探讨苦参素对实验动物性肝癌增生细胞核抗原(PCNA)和白细胞的影响,为肝癌化疗中白细胞降低寻找有效的防治方法。方法将48只肝癌大鼠模型随机分成两组,实验组给以苦参素灌胃。对实验组和对照组进行白细胞、PCNA检测。结果实验组白细胞计数高于对照组;PCNA在对照组中阳性表达20例,在实验组中阳性表达7例。结论苦参素能抑制肝癌细胞的增殖,能有效预防白细胞的降低。

Objective To explore the effect of Kurarinone on PCNA and WBC in liver cancer animal model.To search effective trestment for leukopenia attributable to chemotherapy in liver cancer. Methods 48 liver cancer animals were divided into two groups and treatment group was treated with Kurd. PCNA and WBC were examined in two groups. Results The numbers of WBC in treatment group were more than control group. There are 7 cases expressing PCNA in treatment group,but 20 cases in control group. Conclusion Kurarinone can repress growth of liver cancer cell and reduce leukopenia attributable to chenotherapy in liver cancer.