纳洛酮治疗儿童外伤性脑梗塞的疗效观察

Assessment of clinical effects of naloxone in treating patients with post-traumatic cerebral infarction of children

目的总结纳洛酮治疗儿童外伤性脑梗塞治疗中的疗效。方法选择46例儿童外伤性脑梗塞患儿,随机分为常规药物治疗组和纳洛酮治疗组,每组各23例,分别于入院当天起采用常规药物治疗及加用盐酸纳洛酮治疗,疗程10d,比较两组治疗前后临床症状、NIHS评分及Barthel指数评分。结果治疗前两组NIHS评分比较,差异无统计学意义(P>0.05),治疗后两组NIHS评分比较,差异有统计学意义(P﹤0.05)。治疗前两组Barthel指数评分比较,差异无统计学意义(P>0.05),治疗后Barthel指数评分比较,差异有统计学意义(P﹤0.05)。纳洛酮治疗组21例临床症状明显好转,常规药物治疗组15例临床症状明显好转,总有效率分别为91%和70%,差异有统计学意义(P﹤0.05)。结论纳洛酮作为一种神经保护剂,能促进神经功能恢复,有效改善外伤性脑梗塞患儿的疗效和预后。

Objective To assess the effect of naloxone on children with post- traumatic infarction and explore its treatment method. Methods 46 children with post-traumatic cerebral infarction were randomly divided into two groups （each 23 cases）. Experiment group received routine therapy plus naloxone and control group received routine therapy only. At the day starting treatment after hospitalization, 10 days as a course of treatment, the clinical symptoms, NIH stroke scale （NIHS） score and Barthel index score before and after treatment were compared in the two groups. Results 21 patient clinical symptoms in the experiment group were obviously improved, but only 15 cases in the control group were obviously improved （91% vs. 70%）. There was significant difference between the two groups. NIHS and Barthel index scores were not statistically different （p〉0.05） between two groups before therapy, but there was statistical difference between the two groups after therapy （all p〈0.05）. Conclusions naloxone as a neunoprotective agent could rapidly promote neurofunction recovery. So it has better efficacy in treating Dost-tramatic cerebral infarction of children.