血液感染的病原学变化及耐药分析

Analysis of drug fast and changes of aetiology of blood infected

目的了解血液感染的病原学变化及耐药状况。方法对蚌埠医学院附属医院2003年3月至2004年3月的临床血液普通培养标本分离鉴定,将鉴定出的76株病原菌及药物敏感性资料进行回顾性分析。结果临床血液普通培养标本793例,分离鉴定所得76株病原菌,阳性率9.6%,以血浆凝固酶阴性葡萄球菌(34株)、大肠埃希菌(17株)为主。表皮葡萄球菌对丁胺卡那霉素、头孢唑啉较为敏感;大肠埃希菌对常用抗生素普遍耐药,尤其对青霉素、氨苄西林、头孢唑啉的耐药率高达100%。结论临床血液感染的细菌趋向多样化,耐药严重的条件致病菌已成为优势感染菌,应重视细菌学检查和耐药性监测,以指导临床合理使用抗菌药物。

Objective To study the condition of drug fast and changes of aetiology of blood infected. Methods The clinical blood samples which were collected from the affiliated hospital of Bengbu medical college from the year of 2003 to 2004.76 strains of pathogenic bacterium and the data of their drug sensitivity were analyzed retrospectively. Results 76 strains of patho-gens were separated from the 793 strains of clinical blood cultivated samples. The rate of masccline was 9.6%. The main patho- genic bacterium were plasma-coagulase negative staphylococcus （34 strains） and escherichia coli （17 strains）. Staphylococcus epidermidis was sensitive to cefazolin and amikacin. Escherichia coli was generally resistant to the commonly antibiotics and the drug resistant rate, especially to laevomycetin, ampicillin and cefazolin,was 100%. Conclusion The bacterium of clinical blood infected trend to diversification, the conditional pathogenic bacteria of severe drug fast will be to become the superiority infected bacterium. Inspection of bacteriology and monitoring of drug resistance shoulde be regarded in order to guide the use of antibacte- rials rationally in clinic.