轮状病毒肠炎患儿血清心肌酶谱的变化及临床意义

Clinical significance and changes of serum myocardial enzyme spectrum in children with rotavirus enteritis

目的研究轮状病毒性肠炎患儿心肌酶谱变化及临床意义。方法检测212例轮状病毒性肠炎患儿(观察组)和186例非轮状病毒性肠炎患儿(对照组)的心肌酶活性并进行比较。结果观察组轮状病毒性肠炎患儿血清谷草转氨酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)和羟丁酸脱氢酶(HBDH)活性均明显高于对照组非轮状病毒性肠炎患儿(P<0.05,P<0.01);合并中、重度脱水的轮状病毒性肠炎患儿血清AST、LDH、CK、CK-MB和HBDH活性明显高于无脱水及轻度脱水者(P<0.05,P<0.01)。结论轮状病毒性肠炎患儿的心肌酶测定对明确诊断、监测患儿病情变化及指导治疗有重要的临床意义。

Objective To evaluate the clinical significance and changes of serum myocardial enzyme spectrum in in children with rotavirus enteritis. Methods The serum myocardial enzyme activity in 212 children with rotavirus enteritis（ observation group） and 186 children with non-rotavirus enteritis（ control group） were detected and compared. Results The activity of AST,LDH,CK,CK-MB and HBDH were higher in observation group than that in control group（ P 〈 0.05 ,P 〈 0.01 ）, and they were higher in children with midrange and severe dehydration than that in children without dehydration and with low-grade dehydration（ P 〈 0.05 ,P 〈 0.01 ）. Conclusion Determination of myocardial enzymatic of chilaren with rotavirus enteritis has important clinical significance to final diagnosis, monitoring the change of pathogenetic condition and guiding treatment.