摘要
[目的]研究多西紫杉醇(TAT)、长春瑞滨(NVB)联合方案在转移性乳腺癌治疗中的疗效及毒副反应。[方法]采用多西紫杉醇75mg/m2,静滴,d1,长春瑞滨25mg/m2,静滴,d1、8,每21d为1周期,完成2周期后开始评价疗效,随访7~24个月。[结果]完全缓解(CR)31.25%(10/32),部分缓解(PR)43.75%(14/32),稳定(SD)25.0%(8/32)。无疾病进展者,总有效率(ORR)为(CR+PR)75.0%(24/32)。毒性反应主要为白细胞降低III-IV度为75.0%,胃肠道反应轻微。[结论]TAT联合NVB(TN方案)治疗转移性乳腺癌疗效显著,不良反应可耐受。
[Objective] To investigate the therapeutic effect and toxicity of combination chemotherapy with TAT and NVB on metastatic breast cancer. [ Methods] Patients were treated every 21 days as a cycle with combination chemotherapy of TAT at the level of 75 mg/m^2 ( 1st day ) and NVB at the level of 25 mg/m^2 ( 1st day, 8th day ) . The curative effect was evaluated after two weeks' therapy and all patients were followed up for 7-24 months. [ Results ] Among all the patients with metastasis treated by combination chemotherapy, the rate of CR was 31.25% (10/32), the rate of PR was 43.75% (14/32), the rate of SD was 25% (8/32), Among patients with PD, ORR was (CR+PR) 75.0% (24/32) . The main toxicity was leucopenia, of which 75% was Grade III and Grade IV. Gastrointestinal negative reaction was minor. [ Conclusion] The combination chemotherapy with TAT and NVB is effective in treating metastatic breast cancer.
出处
《现代预防医学》
CAS
北大核心
2007年第13期2579-2580,2582,共3页
Modern Preventive Medicine