多西紫杉醇联合长春瑞滨治疗转移性乳腺癌的疗效分析

ANALYSIS OF THERAPEUTIC EFFECT OF COMBINATION CHEMOTHERAPY WITH TAT AND NVB ON METASTATIC BREAST CANCER

[目的]研究多西紫杉醇(TAT)、长春瑞滨(NVB)联合方案在转移性乳腺癌治疗中的疗效及毒副反应。[方法]采用多西紫杉醇75mg/m2,静滴,d1,长春瑞滨25mg/m2,静滴,d1、8,每21d为1周期,完成2周期后开始评价疗效,随访7～24个月。[结果]完全缓解(CR)31.25%(10/32),部分缓解(PR)43.75%(14/32),稳定(SD)25.0%(8/32)。无疾病进展者,总有效率(ORR)为(CR+PR)75.0%(24/32)。毒性反应主要为白细胞降低III-IV度为75.0%,胃肠道反应轻微。[结论]TAT联合NVB(TN方案)治疗转移性乳腺癌疗效显著,不良反应可耐受。

[Objective] To investigate the therapeutic effect and toxicity of combination chemotherapy with TAT and NVB on metastatic breast cancer. [ Methods] Patients were treated every 21 days as a cycle with combination chemotherapy of TAT at the level of 75 mg/m^2 （ 1st day ） and NVB at the level of 25 mg/m^2 （ 1st day, 8th day ） . The curative effect was evaluated after two weeks＇ therapy and all patients were followed up for 7-24 months. [ Results ] Among all the patients with metastasis treated by combination chemotherapy, the rate of CR was 31.25% （10/32）, the rate of PR was 43.75% （14/32）, the rate of SD was 25% （8/32）, Among patients with PD, ORR was （CR＋PR） 75.0% （24/32） . The main toxicity was leucopenia, of which 75% was Grade III and Grade IV. Gastrointestinal negative reaction was minor. [ Conclusion] The combination chemotherapy with TAT and NVB is effective in treating metastatic breast cancer.