经冠状动脉自体骨髓单个核细胞移植对急性前壁心肌梗死左室重构的影响
摘要
急诊PCI是急性心肌梗死的首选治疗方法。它可以快速和充分地恢复心肌组织的血流。但冠状动脉一旦闭塞,短时间内心肌坏死很快发生.随着心肌梗死区的纤维化和瘢痕形成,梗死区室壁延展变薄,非梗死区胶原纤维增生,发生左室重构,成为后期心功能不全和心源性死亡的主要原因,因而,细胞移植代替梗死心肌的研究已成为国内外研究热点。故本研究中我们试图应用骨髓单个核细胞通过冠脉法进行移植治疗急性前壁心肌梗死,观察其对左室重构的影响,以评价干细胞移植修复梗死心肌和改善心脏功能的可行性及有无不良反应。
出处
《现代预防医学》
CAS
北大核心
2007年第13期2599-2600,共2页
Modern Preventive Medicine
参考文献10
-
1Pfeifer MA,Braunwald E.Ventricular remodeling after myocardial infarction:experimental observations and clinical implications[J].Circulation,1990,81 (4):1161-1172.
-
2Brit ten MB,Abolmaali ND,Assmus B,et al.Infarct remodeling after int racoronary progenitor cell treatment in patient s wit h acute myocardial infarction (TOPCARE-AMI):mechanistic insights f rom serial cont rastenhanced magnetic resonance imaging[J].Circulation,2003,108 (18):2212-2218.
-
3Rashkind WJ.Transcat heter treatment of congenital heart disease[J].Circulation,1983,67 (4):711-716.
-
4Lock J E,Rome JJ,Davis R,et al.Transcat heter closure of at rial septal defects.Experimental studies[J].Circulation,1989,79 (5):1091-1099.
-
5Hakuno D,Fukda K,Makino S,et al.Bone marrow2 derived regenerated cardiomyocytes (CMG Cells) express functional adrenergic and muscarinic receptors[J].Circulation,2002,105 (3):380-386.
-
6葛均波,李延林,钱菊英,史剑慧,王齐兵,牛玉宏,潘翠珍,樊冰,黄国倩,刘学波.陈旧性前壁心肌梗死患者自体骨髓单个核细胞移植后左室心肌灌注及收缩功能的变化[J].中国介入心脏病学杂志,2004,12(5):261-264. 被引量:20
-
7St rauer BE,Brehm M,Zeus T,et al.Repair of infarcted myocardium by autologous int racoronary mononuclear bone marrow cell transplantation in human[J].Circulation,2002,106 (15):1913-1918.
-
8Bodo ES,Michael B,Tobias Z,et al.Repair of inf racted myocardium by autologous bone marrow cell transplantation in humans[J].Circulation,2002,106 (15):1913.
-
9Kang HJ,Kim HS,Zhang SY,et al.Effect s of intracoronary infusion of peripheral blood stem-cells mobilized wit h granulocytecolony stimulating factor on left vent ricular systolic function and restenosis after coronary stenting in myocardial infarction:t he MAGIC cell rangomised clinical t rial[J].Lancet,2004,363(9411):751-756.
-
10Kai W,Gend P,Joachim L,et al.Intracoronary autologous bonemarrow cell transfer after myocardial infarction:the BOOST randomized cont rolled clinical trail[J].Lancet,2004,364 (9429):141-148.
二级参考文献11
-
1Kamihata H, Matsubara H, Nishiue T, et al. Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines. Circulation, 2001,109:
-
2Britten MB, Abolmaali ND, Assmus B, et al. Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI): mechanistic insights from serial contrast-enhanced magnetic resonance imaging. Circulat
-
3Kimikazu H, Tao SL, Toshiro K, et al. Therapeutic angio genesis induced by local autologous bone marrow cell implantation. Ann Thorac Surg, 2002,73:1210.
-
4Perin EC, Dohmann H, Borojevic R, et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation, 2003,107:2294-2302.
-
5Braown KA. Prognostic value of thallium-201 myocardial perfusion imagine: A diagnostic tool comes of age. Circulation, 1991,83,363.
-
6Nygren JM, Jovinge S, Breitbach M, et al. Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med, 2004,10:494-501.
-
7Murry CE, Soonpaa MH, Reinecke H, et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature, 2004,428:664-668.
-
8Giuliana F, Gabriella C, De A, et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science, 1997,279:1528-1530.
-
9Shinji M, Keiichi F, Shunichirou M, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest, 1999,103:697-705.
-
10Donald O, Jan K, Stefano C, et al. Bone marrow cells regenerate infarcted myocardium. Nature, 2001,410:701-705.
共引文献19
-
1赵嫣,葛均波,张少衡,钱菊英,孙爱军,王克强,史剑慧,胡凯,邹云增.骨髓干细胞移植治疗心肌梗死最佳时间段的选择[J].中国临床医学,2005,12(2):192-195. 被引量:13
-
2刘健,王伟民,孙宁玲,张萍,刘开彦,汪素,王茜,臧越,杨松娜,王靖,陆道培,郭继鸿.前壁心肌梗死患者自体骨髓单个核细胞移植治疗的可行性研究[J].中国介入心脏病学杂志,2005,13(2):76-80. 被引量:1
-
3葛均波,张少衡.干细胞能再生梗死心肌吗?[J].中华医学杂志,2005,85(36):2530-2532. 被引量:3
-
4张少衡,葛均波,钱菊英,孙爱军,潘为民,林谨仪,徐丹令,胡海峰,张峰,马剑英,姚康,王齐兵,刘学波,姚瑞明,沈安,崔珊静,王灏,冯琪,邹云增,王克强,胡凯.经冠状动脉内自体骨髓干细胞移植对不同基础心功能影响及其机制探讨[J].中国临床医学,2005,12(6):993-995.
-
5王伟民,孙宁玲,刘健,张萍,刘开彦,王茜,杨松娜,汪素琴,藏越,郭继鸿.经冠状动脉注入自体骨髓单个核细胞的临床研究[J].中华心血管病杂志,2006,34(2):103-106. 被引量:20
-
6黄榕翀,葛均波.干细胞移植治疗心肌坏死的基础与临床研究[J].基础医学与临床,2006,26(4):344-348. 被引量:1
-
7许丹,尚小明,姜玉如,纪征,姜玉凤,卢峰,张春来,李霞.自体骨髓单个核细胞移植对急性前壁心肌梗死左室重构的影响[J].临床荟萃,2006,21(14):1011-1013.
-
8刘满江,胡雪松.心肌梗死的干细胞移植治疗新进展[J].中国医学文摘(内科学),2006,27(4):308-310. 被引量:2
-
9李佳(综述),窦克非(校).干细胞移植治疗心脏疾患存在的问题及其研究进展[J].中国分子心脏病学杂志,2006,6(4):233-236.
-
10王玉红,陈光辉.国内干细胞移植治疗心血管疾病的临床研究与应用进展[J].中国组织工程研究与临床康复,2007,11(24):4794-4797. 被引量:2
-
1许丹,尚小明,姜玉如,纪征,姜玉凤,卢峰,张春来,李霞.经冠状动脉自体骨髓单个核细胞移植治疗急性前壁心肌梗死的研究[J].中国心血管杂志,2006,11(4):261-265. 被引量:4
-
2李素梅,蔡恒,宋雅玲,刘晓英.心理护理干预对急性前壁心肌梗死疗效的影响[J].护理研究(中旬版),2005,19(12):2663-2664. 被引量:2
-
3杨廷发,马卫华,候南兰.蝮蛇抗栓酶治疗冠心病的血液流变学观察[J].中国血液流变学杂志,1993,3(2):39-40.
-
4沈菲.1例急性心肌梗死并发室颤后行药物溶栓患者的抢救护理[J].中国民康医学,2013,25(7):111-112. 被引量:9
-
5李艳萍.一例经皮外周干细胞心肌移植病人的护理[J].护士进修杂志,2004,19(9):862-862.
-
6张杨.一例急性心肌梗死患者应用主动脉内球囊反搏术护理体会[J].中国卫生产业,2011,8(01Z):26-26.
-
7杜小建.医嘱执行不到位 医方负主要责任[J].中国社区医师,2011,27(35):24-24.
-
8邢非,康晓燕,高传玉.自体骨髓单个核细胞移植对急性心肌梗死患者生活质量的影响[J].中国实用医刊,2008,35(10):13-15.
-
9刘玉梅.急性心肌梗死1例急救与护理[J].中国社区医师(医学专业),2009,11(7):118-119.
-
10张优佳,高茜,王黎黎,张静.应激性高血糖对急性心肌梗死患者预后的影响[J].中国现代药物应用,2014,8(19):45-46. 被引量:1