诺维本联合大剂量顺铂方案治疗晚期非小细胞肺癌疗效分析

Analysis the effect of navelbine and cisplatin in treatment of advanced non-small cell lung cancer

目的观察诺维本联合大剂量顺铂方案治疗晚期非小细胞肺癌的疗效和毒性。方法32例Ⅲ、Ⅳ非小细胞肺癌病人,用诺维本25mg/m2,第1、8天,顺铂80mg/m2,第1天,联合化疗。21d为1个周期,治疗2个周期以上评价疗效。结果32例病人总有效率43.75%(14/32),其中CR1例(3.12%),PR13例(40.6%)。毒性反应主要是为骨髓抑制,Ⅱ、Ⅲ度白细胞下降占59.37%;胃肠道反应以Ⅰ、Ⅱ度明显(68.75%),Ⅲ度不多(12.5%),无治疗相关死亡。结论诺维本联合顺铂方案治疗晚期非小细胞肺癌近期疗效满意,毒性可以耐受。

[Objective] To observe the short-term effectiveness and toxicity of using navelbine and cisplatin for medical chemotherapy in treating advanced non-small cell lung cancer, [Methods] Thirty-two cases of Grades Ⅲ-Ⅳ non-small cell lung cancer were given navelbine 25 mg/m^2 iv dl, dS; cisplatin 80 mg/m^2 ivgtt dl of combined chemotherapy. Repeated 21 day, At least 2 cycles for evaluating response and toxicity. [Results] The total response rate was 43,75% one case CR（3.12%）, thirteen case PR（40.6%）. The main toxic side-effects included marrow-sup- pression, nausea and phlebitis. [Conclusion] Navelbine plus cisplatin regiment is rather effective in treating advanced non-small cell lung cancer with tolerated side-effects.