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中性粒细胞弹性蛋白酶与慢性阻塞性肺疾病 被引量：8

Neutrophil elastase and chronic obstructive pulmonary disease
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摘要 中性粒细胞弹性蛋白酶是丝氨酸蛋白酶超家族成员之一,它能够消化、降解细胞外基质和上皮连接结构造成气道上皮完整性破坏和肺组织损伤,并通过促进炎性细胞聚集,引起黏液高分泌等机制促进慢性阻塞性肺疾病气道炎症与重构的发生。 Neutrophil elastase is a potent serine proteinase, it can cause epithelial damage and destruction of lung tissue by digesting, degradating extracellular matrix and epithelium connective frame. Neutrophil elastase also plays a crucial role in the pathogenesis of airway inflammation and remodeling in COPD by causing inflammatory cells mucin accumulation and hypersecretion,etc.
作者 李雪华 张洪玉 庞宝森
机构地区 泰安市解放军第八十八医院呼吸科
出处 《国际呼吸杂志》 2007年第13期989-992,共4页 International Journal of Respiration
关键词 中性粒细胞弹性蛋白酶 慢性阻塞性肺疾病 气道重构 Neutrophil elastase Chronic obstructive pulmonary disease Airway remodeling
分类号 R563 [医药卫生—呼吸系统]
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参考文献20

  • 1Kawabata K, Hagio T, Matsumoto S, et al. Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters. Am J Respir Cir Care Med,2000,161:2013-2018.
  • 2Snider GL, Stone PJ, Lucey EC, et al. A polypeptide derived from the medicinal leech, prevents human neutrophil elastase-induced emphysema and bronchial secretory cell metaplasia in the hamster. Am Rev Respir Dis,1985 ,132 :1155-1161.
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二级参考文献51

  • 1周向东,杨肇亨,黄勇.急性肺损伤时肺血管床中性粒细胞滞留的分子基础研究[J].中华内科杂志,1996,35(8):556-556. 被引量：7
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  • 7[7]Kishioka C, Okamoto K, Kim J, et al. Regulation of secretion from mucous and serous cells in the excised ferret trachea. Respir Physiol, 2001, 126(2): 163-171.
  • 8[8]Takeyama K, Dabbagh K, Lee HM, et al. Epidermal growth factor system regulates mucin production in airway. Pro Natl Acad Sci USA, 1999, 96(6): 3081-3086.
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  • 10[10]Fischer BM, Voynow JA. Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species. Am J Respir Cell Mol Biol, 2002, 26(4):447-452.

共引文献26

同被引文献61

二级引证文献49

国际呼吸杂志
2007年 第13期

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