肺γδT细胞与气道反应性关系的研究进展

Reseach progress of relationship between lung γδT cells and airway reactivity

T细胞根据其表面受体的不同可以分为γδT细胞和αβT细胞。前者仅占外周血淋巴细胞的1%～10%,在皮下、肠黏膜、呼吸道、泌尿生殖系统黏膜中分布较多。近来发现肺γδT细胞在调节气道反应性中发挥着一定的作用,它能抑制气道高反应性（AHR）;促进AHR,或者对其无影响。其原因可能是肺γδT细胞亚群不同所致。Vγ4^＋γδT细胞能抑制AHR,而Vγ1^＋γδT细胞则能增加AHR,但其影响因素较多,如环境因素、年龄因素等等。

T lymphocytes, according to their surface receptors, include gamma/delta T cells and alpha/beta T cells. Gamma/delta T cells, which exist mainly in subcutaneous tissue, intestinal mucosa, respiratory tract,and urogenital system mucosa,only occupy 1% to 10% of peripheral blood lymphocytes. Recently, people found lung gamma/delta T cells contribute to the airway reactivity regulation, some gamma/delta T cells can supress the airway hyperreactivity,some can promote the airway hyperreactivity,some even have no effect on it, It is due to the different cell subsets. Vγ4^＋ gamma/delta T cells can suppress the airway hyperreactivity,otherwise, Vγ1^＋ gamma/delta T cells can promote the airway hyperreactivity. But the influential factors are more,like as environmental agents,age factor and so on.