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肺γδT细胞与气道反应性关系的研究进展 被引量:1

Reseach progress of relationship between lung γδT cells and airway reactivity
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摘要 T细胞根据其表面受体的不同可以分为γδT细胞和αβT细胞。前者仅占外周血淋巴细胞的1%~10%,在皮下、肠黏膜、呼吸道、泌尿生殖系统黏膜中分布较多。近来发现肺γδT细胞在调节气道反应性中发挥着一定的作用,它能抑制气道高反应性(AHR);促进AHR,或者对其无影响。其原因可能是肺γδT细胞亚群不同所致。Vγ4^+γδT细胞能抑制AHR,而Vγ1^+γδT细胞则能增加AHR,但其影响因素较多,如环境因素、年龄因素等等。 T lymphocytes, according to their surface receptors, include gamma/delta T cells and alpha/beta T cells. Gamma/delta T cells, which exist mainly in subcutaneous tissue, intestinal mucosa, respiratory tract,and urogenital system mucosa,only occupy 1% to 10% of peripheral blood lymphocytes. Recently, people found lung gamma/delta T cells contribute to the airway reactivity regulation, some gamma/delta T cells can supress the airway hyperreactivity,some can promote the airway hyperreactivity,some even have no effect on it, It is due to the different cell subsets. Vγ4^+ gamma/delta T cells can suppress the airway hyperreactivity,otherwise, Vγ1^+ gamma/delta T cells can promote the airway hyperreactivity. But the influential factors are more,like as environmental agents,age factor and so on.
出处 《国际呼吸杂志》 2007年第13期1028-1030,共3页 International Journal of Respiration
基金 广西自然科学基金(编号:桂科基0448056)
关键词 细胞受体γδ T细胞 气道反应性 Cell receptor gamma/delta T cell Airway reactivity
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  • 1Brenner MB, Mclean J, Dialynas DP, et al. Identification of a putatire second T-cell receptor. Nature, 1986,322 : 145-149.
  • 2Augustin A, Kubo RT, Sim GK. Resident pulmonary lymphocytes expressing the γ/δ T-cell receptor. Nature, 1989, 340:239-241.
  • 3Sim GK, Rajaserkar R, Dessing M, et al. Homing and in situ differentiation of resident pulmonary lymphocytes. Int Immunol, 1994,6 : 1287-1295.
  • 4Sperling AI, Cron RQ, Decker DC, et al. Peripheral T cell receptor gamma delta variable gene repertoire maps to the T cell receptor loci and is influenced by positive selection. J Immunol, 1992,149 : 3200-3207.
  • 5Wands JM, Roark CL, Aydintug MK, et al. Distribution and leukocyte contacts of γδT cells in the lung. J Leukoc Biol, 2005, 78: 1086-1096.
  • 6Lahn M, Kanehiro A, Takeda K, et al. Negative regulation of airway responsiveness that is dependent on γδT cells and independent of T cells. Nat Med, 1999,5 : 1150-1156.
  • 7Hahn YS,Taube C,Jin N,et al. Different Potentials of γδT Cell Subsets in Regulating Airway Responsiveness: Vγ1^+ Cells, but Not Vγ4^+ Cells, Promote Airway Hyperreactivity, Th2 Cytokines, and Airway Inflammation. J Immunol, 2004, 172: 2894-2902.
  • 8Cui ZH, Joetham A, Aydintug MK, et al. Reversal of allergic airway hyperreactivity after long-term allergen challenge depends on γδT cells. Am J Respir Crit Care Med, 2003,168: 1324-1332.
  • 9Schramm CM, Puddington L, Ovalbumin Exposure Induces Wu C, et al. Chronic Inhaled Antigen-Dependent hut Not Antigen-Specific Inhalational Tolerance in a Murine Model of Allergic Airway Disease. Am J Pathol,2004,164:295-300.
  • 10Hahn YS,Taube C,Jin N,et al. Vγ4^+ γδT cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice. J Immunol, 2003,171 : 3170-3178.

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