川芎嗪配合CVP监测在防治外伤性脑梗死中的疗效观察

Clinical Observation on Ugustrazine Combined with Central Venous Pressure Monitoring in Preventing and Curing Traumatic Cerebral infarction

目的:观察川芎嗪配合中心静脉压(CVP)监测在防治外伤性脑梗死中的临床疗效。方法:将96例患者随机分为2组,对照组43例,采用西医常规治疗;治疗组53例,在西医常规治疗的同时,配合中心静脉压监测及川芎嗪针静脉滴注治疗。观察2组临床疗效、脑梗死发生率、格拉斯哥(CCS)评分。结果:治疗组治愈率、总有效率(52．83％、81．13％)均高于对照组(44．19％、67．44％),差异有显著性意义(P<0．05)。治疗后脑梗死发生率治疗组明显低于对照组,差异有非常显著性意义(P<0．01)。2组治疗后GCs评分均较治疗前提高(P<0．01),但治疗组提高的幅度高于对照组(P<0．05)。结论:川芎嗪配合中心静脉压监测治疗重型颅脑损伤早期患者,能够显著地降低外伤性脑梗死发生率,提高CCS评分,改善患者临床症状,减少并发症,提高临床治愈率。

Objective: To observe the therapeutic effect of liguatrazine combined with central venous pressure (CVP) monitoring in preventing and curing traumatic cerebral infarction (TCI). Methods: Ninety-six TCI patients were randomized into two groups: both of the treatment group and the control group received routine western medicine, and the treatment received ligustrazine combined with CVP monitoring additionally. After treatment, the therapeutic effect, incidence of cerebral infarction and scores of Glasgow Coma Scale (CCS) were compared in the two groups. Results: The cure rate and the total effective rate were 52. 83% and 81. 13% in the treatment respectively, which were superior to 44. 19% and 67. 44% in the control group ( P < 0.05). The incidence of cerebral infarction was lower in the treatment ( P < 0.01) . CCS scores were higher after treatment in the two groups than those before treatment ( P < 0. 01), and the increase was obvious in the treatment group ( P < 0.05). Conclusion: Liguatrazine combined with CVP monitoring for severe TCI in early stage can decrease cerebral infarction incidence, increase CCS scores, relief symptoms, reduce complications and increase cure rate.