橘核丸治疗男性免疫性不育症132例疗效观察

Effect of Juhe Pills for Male Immune Infertility: An Obseivation of 132 Cases

目的:观察橘核丸治疗男性免疫性不育症的临床疗效。方法:将264例患者随机分为2组,治疗组132例用橘核丸治疗,对照组132例用强的松治疗。结果:总有效率治疗组为90．91％,对照组为44．70％。2组总有效率比较,差异有非常显著性意义(P<0．01)。抗精于抗体(AsAb)转阴率治疗组为90．91％,对照组为44．70％,2组比较,差异有非常显著性意义(P<0．01)。治疗组治疗前后精于液化时间、精子密度、精子活率和精子畸形率比较,差异均有非常显著性意义(P<0.01);对照组治疗前后比较,差异无显著性意义(P> 0．05)。2组治疗后精子液化时间、精子密度、精子活率和精子畸形率比较,差异均有非常显著性意义(P< 0．01)。配偶受孕率治疗组为56．06％,对照组为19．70％,2组比较,差异有非常显著性意义(P<0．01)。结论:橘核丸治疗男性免疫性不育症有良好的疗效,并能显著提高精子质量。

Objective: To observe the therapeutic effect of Juhe Pills (JP) for the treatment of male immune infertility (MII). Methods: Two hundred and sixty-four MII patients were equally randomized into two groups: the treatment group received JP and the control group received prednisone. Results: The total effective rate was 90.91% in the treatment group, higher than 44.70% in the control group ( P< 0. 01) . The rale of antisperm antibody (AsAb) turning negative was 90. 91% in the treatment group and 44. 70% in the control group, the difference being significant (P < 0.01). The differences of semen liquefaction, sperm density, sperm motility rate, and sperm abnormality rate were significant in the treatment group (P < 0.01) before and after treatment but were insignificant in the control grou ( P > 0. 05). The above four indexes in treatment group after treatment differed from those in the control group (P < 0.01). The conception rate was 36.06% in the treatment, higher than that in the control group ( P < 0.01). Conclusion: JP has a good effect on MII and can markedly improve the sperm quality.