肾衰合剂对慢性肾衰整体功能代偿及微炎症状态的影响

Effect of Renal Failure Mixture on Holistic Functional Compensation and Micro - inflammation State in Chronic Renal Failure

目的:观察肾衰合剂对慢性肾衰患者的整体功能代偿及微炎症状态的影响。方法:将138患者随机分为2组。对照组69例,以西医常规方法治疗;治疗组69例,在对照组治疗基础上加服肾衰合剂(组成:黄芪、补骨脂、淫羊藿、鹿衔草、鱼腥草、白术、当归、大黄、茯苓、川芎、菟丝子、何首乌)。观察2组临床疗效、治疗前后血肌酐(Cr)、内生肌酐清除率(CCr)、C反应蛋白(CRP)及白介素-6(IL-6)变化。结果:总有效率治疗组为88．41％,对照组为57．97％,2组比较,差异有非常显著性意义(P<0．01)。2组治疗后Cr、CRP、IL-6、Ccr均有显著改善,治疗前后比较,差异有显著性或非常显著性意义(P<0．05, P<0．01)。2组治疗后Cr、CRP、IL-6、CCr比较,差异有显著性或非常显著性意义(P<0．05,P<0．01),治疗组优于对照组。结论:肾衰合剂能促进慢性肾衰患者整体功能代偿及微炎症状态的改善。

Objective: To oberve the effect of Renal Failure Mixture (RFM) on holistic functional compensation and micro - inflammation Mate in chronic renal failure (CRF). Methods: One hundred and thirty -eight CRF patients were equally randomized into two groups: the control group received routine western medicine, and the treatment group received RFM (mainly composed of Radix Astragali, Fractals Pso-raleae, Hema Epimedii, Herba Pylorae Herba Houttuyniae, Rhizoma Atractylodis Macrocephalae, Radix Angelicas Sinensis, Radix et Rhizoma Rhei, Poria, Rhizoma Chuanxiong, Semen Cuacutae, Radix Polygoni Multiflori) additionally. After treatment, the therapeutic effect was compared in the two groups. Meanwhile, the changes of serum creatinine (SCr), creatinine clearance rate (CCr), C-reactive protein (CRP) and interleukin 6 (IL-6) were observe before and after treatment in the two groups. Results: The total effective rate was 88. 31% in the treatment group and 59. 97% in the control group, the difference being significant ( P < 0. 01). The differences of SCr, CCr, CRP and IL-6 were significant in the two groups after treatment as compared with those before treatment (P < 0. OS or P < 0. 01). So did the differences of SCr, CCr, CRP and IL-6 between the two groups after treatment ( P < 0. OS or P < P. 01). Conclusion: RFM can improve the holistic functional compensation and micro - inflammation state in CRF.