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结缔组织生长因子——抗肝纤维化的新靶点 被引量：1

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作者 彭梅娟 郝春秋 白雪帆
机构地区 第四军医大学唐都医院感染病诊疗中心
出处 《肝脏》 2007年第3期197-199,共3页 Chinese Hepatology
基金 国家自然科学基金资助项目(30571658)
关键词 结缔组织生长因子 抗肝纤维化 新靶点 转化生长因子B TGFΒ 生物学作用 组织纤维化 生物学效应
分类号 R575.2 [医药卫生—消化系统]
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参考文献14

  • 1Bradham DM,Igarashi A,Potter RL,et al.Connective tissue growth factor:a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.J cell Biol,1991,114:1285-1294.
  • 2Letterio JJ,Bottinger EP.TGF2beta knockout and dominant-negative receptor transgenic mice.Miner Elect rolyte Metab,1998,24:161-167.
  • 3Ito Y,Goldschmeding R,Bend R,et al.Kinetics of connective tissue growth factor expression during experimental proliferative glomerulongphritis.Am Soc Nephrol,2001,2:472-484.
  • 4Mori T,Kawara S,Shinozake M,et al.Role and interaction of connective tissue growth factor with transforming growth factor-beta in persist fibrosis model.J Cell Physiol,1999,181:153-159.
  • 5Grean J KG,Darren F,Madeline M,et al.The role of P42/44MAPK and protein kinase B in connective tissue growth factor induced extrocellular matrix protein production,cell migration,and actin cytoskeletal rearrangement in human mesangial cell.J Biol Chem,2002,277:44187-44194.
  • 6Leask A,Holmes A,Black CM,et al.CTGF gene regulation:requirements for its induction by TGFbeta 2 in fibroblasts.J Biol Chem,2003,278:5-8.
  • 7Homles A,Abraham DJ.CTGF and SMADs maintenance of scleroderma phenotype is independent of SMADs signaling.J Biol Chem,2001,276:10594-10601.
  • 8Stratton R,Rajkumar V,Ponticos M,et al.FASEB J,2002,16:1949-1951.
  • 9Leask A,Holmes A,Abraham DJ,et al.CTGF gene regulation,requirements for its induction by TGF-β in fibrahlast.J Biol Chem,2003,278:13008-13015.
  • 10Paradis V,Dargere D,Bonvoust F,et al.Effects and regulation of connective tissue growth factor on hepatic stellate cells.Lab Invest,2002,82:2767-2774.

二级参考文献7

  • 1Rachfal AW,Brigstock DR.Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosis.Hepatol Res,2003,26:1-9.
  • 2Paradis V,Dargere D,Vidaud M,et al.Expression of connective tissue growth factor in experimental rat and human liver fibrosis.Hepatology,1999,30:968-976.
  • 3Abou-Shady M,Friess H,Zimmermann A,et al.Connective tissue growth factor in human liver cirrhosis.Liver,2000,20:296-304.
  • 4Williams EJ,Gaca MD,Brigstock DR,et al.Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells.J Hepatol,2000,32:754-761.
  • 5Paradis V,Dargere D,Bonvoust F,et al.Effects and regulation of connective tissue growth factor on hepatic stellate cells.Lab Invest,2002,82:767-774.
  • 6贾继东,Michael Bauer,Gabriele Boigk,Martin Ruelh,Detlef Schuppan,王宝恩.大鼠结缔组织生长因子部分cDNA序列的克隆及其mRNA在实验性肝纤维化中的表达[J].中华肝脏病杂志,2000,8(2):102-104. 被引量：22
  • 7中华医学会传染病与,寄生虫病学分会,肝病学分会.病毒性肝炎防治方案[J].中华肝脏病杂志,2000,8(6):324-329. 被引量：14010

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肝脏
2007年 第3期

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